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Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.
Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1760-1.BM

Abstract

Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. Electronic address: moritah@hoshi.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26923696

Citation

Kaneda, Toshio, et al. "Cyclolinopeptides, Cyclic Peptides From Flaxseed With Osteoclast Differentiation Inhibitory Activity." Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 7, 2016, pp. 1760-1.
Kaneda T, Yoshida H, Nakajima Y, et al. Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity. Bioorg Med Chem Lett. 2016;26(7):1760-1.
Kaneda, T., Yoshida, H., Nakajima, Y., Toishi, M., Nugroho, A. E., & Morita, H. (2016). Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity. Bioorganic & Medicinal Chemistry Letters, 26(7), 1760-1. https://doi.org/10.1016/j.bmcl.2016.02.040
Kaneda T, et al. Cyclolinopeptides, Cyclic Peptides From Flaxseed With Osteoclast Differentiation Inhibitory Activity. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1760-1. PubMed PMID: 26923696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity. AU - Kaneda,Toshio, AU - Yoshida,Haruka, AU - Nakajima,Yuki, AU - Toishi,Minako, AU - Nugroho,Alfarius Eko, AU - Morita,Hiroshi, Y1 - 2016/02/16/ PY - 2016/01/27/received PY - 2016/02/13/revised PY - 2016/02/16/accepted PY - 2016/3/1/entrez PY - 2016/3/1/pubmed PY - 2016/11/8/medline KW - Cyclic peptides KW - Cyclolinopeptides KW - Flaxseed KW - Linum usitatissimum KW - Osteoclast differentiation SP - 1760 EP - 1 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 26 IS - 7 N2 - Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/26923696/Cyclolinopeptides_cyclic_peptides_from_flaxseed_with_osteoclast_differentiation_inhibitory_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(16)30153-6 DB - PRIME DP - Unbound Medicine ER -