Tags

Type your tag names separated by a space and hit enter

Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning.
World Neurosurg 2016; 90:668-674WN

Abstract

BACKGROUND

Three-dimensional (3D) printing holds promise for a wide variety of biomedical applications, from surgical planning, practicing, and teaching to creating implantable devices. The growth of this cheap and easy additive manufacturing technology in orthopedic, plastic, and vascular surgery has been explosive; however, its potential in the field of neurosurgery remains underexplored. A major limitation is that current technologies are unable to directly print ultrasoft materials like human brain tissue.

OBJECTIVE

In this technical note, the authors present a new technology to create deformable, personalized models of the human brain.

METHODS

The method combines 3D printing, molding, and casting to create a physiologically, anatomically, and tactilely realistic model based on magnetic resonance images. Created from soft gelatin, the model is easy to produce, cost-efficient, durable, and orders of magnitude softer than conventionally printed 3D models. The personalized brain model cost $50, and its fabrication took 24 hours.

RESULTS

In mechanical tests, the model stiffness (E = 25.29 ± 2.68 kPa) was 5 orders of magnitude softer than common 3D printed materials, and less than an order of magnitude stiffer than mammalian brain tissue (E = 2.64 ± 0.40 kPa). In a multicenter surgical survey, model size (100.00%), visual appearance (83.33%), and surgical anatomy (81.25%) were perceived as very realistic. The model was perceived as very useful for patient illustration (85.00%), teaching (94.44%), learning (100.00%), surgical training (95.00%), and preoperative planning (95.00%).

CONCLUSIONS

With minor refinements, personalized, deformable brain models created via 3D printing will improve surgical training and preoperative planning with the ultimate goal to provide accurate, customized, high-precision treatment.

Authors+Show Affiliations

Department of Mechanical Engineering, Stanford University, Stanford, California, USA.Department of Neurosurgery, King's College Hospital London, London, United Kingdom.Department of Pediatric Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.Department of Mechanical Engineering, Stanford University, Stanford, California, USA; Department of Bioengineering, Stanford University, Stanford, California, USA. Electronic address: ekuhl@stanford.edu.

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

26924117

Citation

Ploch, Caitlin C., et al. "Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning." World Neurosurgery, vol. 90, 2016, pp. 668-674.
Ploch CC, Mansi CSSA, Jayamohan J, et al. Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning. World Neurosurg. 2016;90:668-674.
Ploch, C. C., Mansi, C. S. S. A., Jayamohan, J., & Kuhl, E. (2016). Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning. World Neurosurgery, 90, pp. 668-674. doi:10.1016/j.wneu.2016.02.081.
Ploch CC, et al. Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning. World Neurosurg. 2016;90:668-674. PubMed PMID: 26924117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning. AU - Ploch,Caitlin C, AU - Mansi,Chris S S A, AU - Jayamohan,Jayaratnam, AU - Kuhl,Ellen, Y1 - 2016/02/24/ PY - 2016/01/16/received PY - 2016/02/15/revised PY - 2016/02/17/accepted PY - 2016/3/1/entrez PY - 2016/3/1/pubmed PY - 2017/8/26/medline KW - 3D printing KW - Clinical skills KW - Neurosurgery KW - Simulation KW - Training SP - 668 EP - 674 JF - World neurosurgery JO - World Neurosurg VL - 90 N2 - BACKGROUND: Three-dimensional (3D) printing holds promise for a wide variety of biomedical applications, from surgical planning, practicing, and teaching to creating implantable devices. The growth of this cheap and easy additive manufacturing technology in orthopedic, plastic, and vascular surgery has been explosive; however, its potential in the field of neurosurgery remains underexplored. A major limitation is that current technologies are unable to directly print ultrasoft materials like human brain tissue. OBJECTIVE: In this technical note, the authors present a new technology to create deformable, personalized models of the human brain. METHODS: The method combines 3D printing, molding, and casting to create a physiologically, anatomically, and tactilely realistic model based on magnetic resonance images. Created from soft gelatin, the model is easy to produce, cost-efficient, durable, and orders of magnitude softer than conventionally printed 3D models. The personalized brain model cost $50, and its fabrication took 24 hours. RESULTS: In mechanical tests, the model stiffness (E = 25.29 ± 2.68 kPa) was 5 orders of magnitude softer than common 3D printed materials, and less than an order of magnitude stiffer than mammalian brain tissue (E = 2.64 ± 0.40 kPa). In a multicenter surgical survey, model size (100.00%), visual appearance (83.33%), and surgical anatomy (81.25%) were perceived as very realistic. The model was perceived as very useful for patient illustration (85.00%), teaching (94.44%), learning (100.00%), surgical training (95.00%), and preoperative planning (95.00%). CONCLUSIONS: With minor refinements, personalized, deformable brain models created via 3D printing will improve surgical training and preoperative planning with the ultimate goal to provide accurate, customized, high-precision treatment. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/26924117/Using_3D_Printing_to_Create_Personalized_Brain_Models_for_Neurosurgical_Training_and_Preoperative_Planning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(16)00326-0 DB - PRIME DP - Unbound Medicine ER -