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Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish.
Mol Neurobiol. 2017 04; 54(3):2114-2125.MN

Abstract

By proteolytic cleavage, matrix metalloproteinases (MMPs) not only remodel the extracellular matrix (ECM) but they also modify the structure and activity of other proteinases, growth factors, signaling molecules, cell surface receptors, etc. Their vast substrate repertoire adds a complex extra dimension of biological control and turns MMPs into important regulatory nodes in the protease web. In the central nervous system (CNS), the detrimental impact of elevated MMP activities has been well-described for traumatic injuries and many neurodegenerative diseases. Nonetheless, there is ample proof corroborating MMPs as fine regulators of CNS physiology, and well-balanced MMP activity is instrumental to development, plasticity, and repair. In this manuscript, we review the emerging evidence for MMPs as beneficial modulators of axonal regeneration in the mammalian CNS. By exploring the multifactorial causes underlying the inability of mature axons to regenerate, and describing how MMPs can help to overcome these hurdles, we emphasize the benign actions of these Janus-faced proteases.

Authors+Show Affiliations

Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium.Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium. Laboratory of Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium.Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium. lies.degroef@bio.kuleuven.be. Laboratory of Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium. lies.degroef@bio.kuleuven.be.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26924318

Citation

Andries, Lien, et al. "Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role From Start to Finish." Molecular Neurobiology, vol. 54, no. 3, 2017, pp. 2114-2125.
Andries L, Van Hove I, Moons L, et al. Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish. Mol Neurobiol. 2017;54(3):2114-2125.
Andries, L., Van Hove, I., Moons, L., & De Groef, L. (2017). Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish. Molecular Neurobiology, 54(3), 2114-2125. https://doi.org/10.1007/s12035-016-9801-x
Andries L, et al. Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role From Start to Finish. Mol Neurobiol. 2017;54(3):2114-2125. PubMed PMID: 26924318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish. AU - Andries,Lien, AU - Van Hove,Inge, AU - Moons,Lieve, AU - De Groef,Lies, Y1 - 2016/02/29/ PY - 2015/12/16/received PY - 2016/02/16/accepted PY - 2016/3/1/pubmed PY - 2018/3/15/medline PY - 2016/3/1/entrez KW - Axonal regeneration KW - Central nervous system KW - Central nervous system injury KW - Central nervous system repair KW - Matrix metalloproteinases SP - 2114 EP - 2125 JF - Molecular neurobiology JO - Mol Neurobiol VL - 54 IS - 3 N2 - By proteolytic cleavage, matrix metalloproteinases (MMPs) not only remodel the extracellular matrix (ECM) but they also modify the structure and activity of other proteinases, growth factors, signaling molecules, cell surface receptors, etc. Their vast substrate repertoire adds a complex extra dimension of biological control and turns MMPs into important regulatory nodes in the protease web. In the central nervous system (CNS), the detrimental impact of elevated MMP activities has been well-described for traumatic injuries and many neurodegenerative diseases. Nonetheless, there is ample proof corroborating MMPs as fine regulators of CNS physiology, and well-balanced MMP activity is instrumental to development, plasticity, and repair. In this manuscript, we review the emerging evidence for MMPs as beneficial modulators of axonal regeneration in the mammalian CNS. By exploring the multifactorial causes underlying the inability of mature axons to regenerate, and describing how MMPs can help to overcome these hurdles, we emphasize the benign actions of these Janus-faced proteases. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/26924318/Matrix_Metalloproteinases_During_Axonal_Regeneration_a_Multifactorial_Role_from_Start_to_Finish_ L2 - https://dx.doi.org/10.1007/s12035-016-9801-x DB - PRIME DP - Unbound Medicine ER -