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Effects of Maxepa on serum lipids in hypercholesterolaemic subjects.
Atherosclerosis 1989; 80(2):119-24A

Abstract

The effect of dietary supplementation with 20 capsules/day Maxepa or olive oil on serum lipids has been studied in 21 hypercholesterolaemic patients using a double-blind crossover design. Platelet membrane eicosapentaenoic acid percentage rose by more than 10-fold after 2 months dietary supplementation with Maxepa. Total serum cholesterol was unchanged and there was a rise in LDL-cholesterol and HDL-cholesterol concentration in men, but no change in LDL-cholesterol, and a fall in HDL-cholesterol in women. In men and women there was a marked fall in total serum triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. Thus, Maxepa is not an effective treatment for isolated hypercholesterolaemia.

Authors+Show Affiliations

Department of Medicine, University of Edinburgh, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2692571

Citation

Dart, A M., et al. "Effects of Maxepa On Serum Lipids in Hypercholesterolaemic Subjects." Atherosclerosis, vol. 80, no. 2, 1989, pp. 119-24.
Dart AM, Riemersma RA, Oliver MF. Effects of Maxepa on serum lipids in hypercholesterolaemic subjects. Atherosclerosis. 1989;80(2):119-24.
Dart, A. M., Riemersma, R. A., & Oliver, M. F. (1989). Effects of Maxepa on serum lipids in hypercholesterolaemic subjects. Atherosclerosis, 80(2), pp. 119-24.
Dart AM, Riemersma RA, Oliver MF. Effects of Maxepa On Serum Lipids in Hypercholesterolaemic Subjects. Atherosclerosis. 1989;80(2):119-24. PubMed PMID: 2692571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Maxepa on serum lipids in hypercholesterolaemic subjects. AU - Dart,A M, AU - Riemersma,R A, AU - Oliver,M F, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 119 EP - 24 JF - Atherosclerosis JO - Atherosclerosis VL - 80 IS - 2 N2 - The effect of dietary supplementation with 20 capsules/day Maxepa or olive oil on serum lipids has been studied in 21 hypercholesterolaemic patients using a double-blind crossover design. Platelet membrane eicosapentaenoic acid percentage rose by more than 10-fold after 2 months dietary supplementation with Maxepa. Total serum cholesterol was unchanged and there was a rise in LDL-cholesterol and HDL-cholesterol concentration in men, but no change in LDL-cholesterol, and a fall in HDL-cholesterol in women. In men and women there was a marked fall in total serum triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. Thus, Maxepa is not an effective treatment for isolated hypercholesterolaemia. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/2692571/Effects_of_Maxepa_on_serum_lipids_in_hypercholesterolaemic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(89)90019-1 DB - PRIME DP - Unbound Medicine ER -