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Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease.
Int Angiol. 2016 Apr; 35(2):111-6.IA

Abstract

This paper focuses on Ruscus aculeatus extract (Ruscus extract) and its combination with hesperidin methyl chalcone (HMC) and ascorbic acid (AA), which have been safely and effectively used in CVD treatment for more than 50 years in some European countries. It presents the effects of that drug on veins and on venous hypertension, its effect on microcirculation and on lymphatics demonstrated by preclinical studies and the clinical evidence issued from clinical trials supporting its use to relieve the symptoms of venous disease. In addition to its venoconstrictive effect on veins, its pharmacological action is on the microcirculation impairment caused by venous hypertension that is at the heart of the pathophysiological mechanism underlying venous disease.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26928296

Citation

Allaert, François-A. "Combination of Ruscus Aculeatus Extract, Hesperidin Methyl Chalcone and Ascorbic Acid: a Comprehensive Review of Their Pharmacological and Clinical Effects and of the Pathophysiology of Chronic Venous Disease." International Angiology : a Journal of the International Union of Angiology, vol. 35, no. 2, 2016, pp. 111-6.
Allaert FA. Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. Int Angiol. 2016;35(2):111-6.
Allaert, F. A. (2016). Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International Angiology : a Journal of the International Union of Angiology, 35(2), 111-6.
Allaert FA. Combination of Ruscus Aculeatus Extract, Hesperidin Methyl Chalcone and Ascorbic Acid: a Comprehensive Review of Their Pharmacological and Clinical Effects and of the Pathophysiology of Chronic Venous Disease. Int Angiol. 2016;35(2):111-6. PubMed PMID: 26928296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. A1 - Allaert,François-A, PY - 2016/3/2/entrez PY - 2016/3/2/pubmed PY - 2017/1/24/medline SP - 111 EP - 6 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 35 IS - 2 N2 - This paper focuses on Ruscus aculeatus extract (Ruscus extract) and its combination with hesperidin methyl chalcone (HMC) and ascorbic acid (AA), which have been safely and effectively used in CVD treatment for more than 50 years in some European countries. It presents the effects of that drug on veins and on venous hypertension, its effect on microcirculation and on lymphatics demonstrated by preclinical studies and the clinical evidence issued from clinical trials supporting its use to relieve the symptoms of venous disease. In addition to its venoconstrictive effect on veins, its pharmacological action is on the microcirculation impairment caused by venous hypertension that is at the heart of the pathophysiological mechanism underlying venous disease. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/26928296/Combination_of_Ruscus_aculeatus_extract_hesperidin_methyl_chalcone_and_ascorbic_acid:_a_comprehensive_review_of_their_pharmacological_and_clinical_effects_and_of_the_pathophysiology_of_chronic_venous_disease_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -