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The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis.
Basic Clin Pharmacol Toxicol. 2016 Sep; 119(3):341-2.BC

Abstract

The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin-resistant manner.

Authors+Show Affiliations

Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.Department of Surgery, University Medical School of Pecs, Pecs, Hungary.Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary. Department of Pharmacognosy, University Medical School of Pecs, Pecs, Hungary.Department of Surgery, University Medical School of Pecs, Pecs, Hungary.Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26928772

Citation

Sandor, Zsolt, et al. "The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis." Basic & Clinical Pharmacology & Toxicology, vol. 119, no. 3, 2016, pp. 341-2.
Sandor Z, Dekany A, Kelemen D, et al. The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis. Basic Clin Pharmacol Toxicol. 2016;119(3):341-2.
Sandor, Z., Dekany, A., Kelemen, D., Bencsik, T., Papp, R., & Bartho, L. (2016). The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis. Basic & Clinical Pharmacology & Toxicology, 119(3), 341-2. https://doi.org/10.1111/bcpt.12574
Sandor Z, et al. The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis. Basic Clin Pharmacol Toxicol. 2016;119(3):341-2. PubMed PMID: 26928772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis. AU - Sandor,Zsolt, AU - Dekany,Andras, AU - Kelemen,Dezsö, AU - Bencsik,Timea, AU - Papp,Robert, AU - Bartho,Lorand, Y1 - 2016/04/01/ PY - 2015/12/15/received PY - 2016/02/23/accepted PY - 2016/3/2/entrez PY - 2016/3/2/pubmed PY - 2017/3/10/medline SP - 341 EP - 2 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin Pharmacol Toxicol VL - 119 IS - 3 N2 - The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin-resistant manner. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/26928772/The_TRPA1_Activator_Allyl_Isothiocyanate__AITC__Contracts_Human_Jejunal_Muscle:_Pharmacological_Analysis_ L2 - https://doi.org/10.1111/bcpt.12574 DB - PRIME DP - Unbound Medicine ER -