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Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues.
Angew Chem Int Ed Engl 2016; 55(14):4537-41AC

Abstract

Stretchable electrochemical sensors are conceivably a powerful technique that provides important chemical information to unravel elastic and curvilinear living body. However, no breakthrough was made in stretchable electrochemical device for biological detection. Herein, we synthesized Au nanotubes (NTs) with large aspect ratio to construct an effective stretchable electrochemical sensor. Interlacing network of Au NTs endows the sensor with desirable stability against mechanical deformation, and Au nanostructure provides excellent electrochemical performance and biocompatibility. This allows for the first time, real-time electrochemical monitoring of mechanically sensitive cells on the sensor both in their stretching-free and stretching states as well as sensing of the inner lining of blood vessels. The results demonstrate the great potential of this sensor in electrochemical detection of living body, opening a new window for stretchable electrochemical sensor in biological exploration.

Authors+Show Affiliations

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. whhuang@whu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26929123

Citation

Liu, Yan-Ling, et al. "Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues." Angewandte Chemie (International Ed. in English), vol. 55, no. 14, 2016, pp. 4537-41.
Liu YL, Jin ZH, Liu YH, et al. Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues. Angew Chem Int Ed Engl. 2016;55(14):4537-41.
Liu, Y. L., Jin, Z. H., Liu, Y. H., Hu, X. B., Qin, Y., Xu, J. Q., ... Huang, W. H. (2016). Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues. Angewandte Chemie (International Ed. in English), 55(14), pp. 4537-41. doi:10.1002/anie.201601276.
Liu YL, et al. Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues. Angew Chem Int Ed Engl. 2016 Mar 24;55(14):4537-41. PubMed PMID: 26929123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues. AU - Liu,Yan-Ling, AU - Jin,Zi-He, AU - Liu,Yan-Hong, AU - Hu,Xue-Bo, AU - Qin,Yu, AU - Xu,Jia-Quan, AU - Fan,Cui-Fang, AU - Huang,Wei-Hua, Y1 - 2016/03/01/ PY - 2016/02/04/received PY - 2016/3/2/entrez PY - 2016/3/2/pubmed PY - 2016/12/15/medline KW - electrochemical detection KW - endothelial cells KW - gold nanotubes KW - stretchable sensor KW - vascular tissue SP - 4537 EP - 41 JF - Angewandte Chemie (International ed. in English) JO - Angew. Chem. Int. Ed. Engl. VL - 55 IS - 14 N2 - Stretchable electrochemical sensors are conceivably a powerful technique that provides important chemical information to unravel elastic and curvilinear living body. However, no breakthrough was made in stretchable electrochemical device for biological detection. Herein, we synthesized Au nanotubes (NTs) with large aspect ratio to construct an effective stretchable electrochemical sensor. Interlacing network of Au NTs endows the sensor with desirable stability against mechanical deformation, and Au nanostructure provides excellent electrochemical performance and biocompatibility. This allows for the first time, real-time electrochemical monitoring of mechanically sensitive cells on the sensor both in their stretching-free and stretching states as well as sensing of the inner lining of blood vessels. The results demonstrate the great potential of this sensor in electrochemical detection of living body, opening a new window for stretchable electrochemical sensor in biological exploration. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/26929123/Stretchable_Electrochemical_Sensor_for_Real_Time_Monitoring_of_Cells_and_Tissues_ L2 - https://doi.org/10.1002/anie.201601276 DB - PRIME DP - Unbound Medicine ER -