Tags

Type your tag names separated by a space and hit enter

Barrier methods of contraception and the risk of cervical neoplasia.
Contraception. 1989 Nov; 40(5):519-30.C

Abstract

The relationship between the use of barrier contraception methods and the risk of cervical neoplasia was analyzed using data from a case-control study conducted in the greater Milan area, northern Italy. A total of 367 cases of invasive cancer under 60 years of age were compared with 323 subjects in hospital for acute conditions unrelated to any of the established or suspected risk factors for cervical cancer, and 316 cases of cervical intraepithelial neoplasia were compared with 258 outpatient controls. Ever-use of barrier methods (condom and diaphragm) was reported by 6% of the cases of invasive cancer and 12% of hospital controls. Corresponding values for intraepithelial neoplasia were 16% for cases and 22% for outpatient controls. Considering the total use of barrier methods, compared to never use, the relative risk of invasive cervical cancer was 0.4 (95% confidence interval 0.2-0.9) and decreased with duration of use (chi 2(1), trend = 5.18, p = 0.02). Likewise, use of barrier methods lowered the risk of intraepithelial neoplasia; the estimated relative risks were 0.9 in users for less than two years and 0.6 for two or more (chi 2(1), trend = 4.61, p = 0.03). Although the protection for invasive cancer appeared to be greater at older ages and in multiparous women, the relative risks were not significantly heterogeneous in various strata of parity, number of sexual partners, oral contraceptive use and history of Pap smears.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

2692961

Citation

Parazzini, F, et al. "Barrier Methods of Contraception and the Risk of Cervical Neoplasia." Contraception, vol. 40, no. 5, 1989, pp. 519-30.
Parazzini F, Negri E, La Vecchia C, et al. Barrier methods of contraception and the risk of cervical neoplasia. Contraception. 1989;40(5):519-30.
Parazzini, F., Negri, E., La Vecchia, C., & Fedele, L. (1989). Barrier methods of contraception and the risk of cervical neoplasia. Contraception, 40(5), 519-30.
Parazzini F, et al. Barrier Methods of Contraception and the Risk of Cervical Neoplasia. Contraception. 1989;40(5):519-30. PubMed PMID: 2692961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Barrier methods of contraception and the risk of cervical neoplasia. AU - Parazzini,F, AU - Negri,E, AU - La Vecchia,C, AU - Fedele,L, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez KW - Age Factors KW - Barrier Methods KW - Biology KW - Cancer KW - Cervical Cancer KW - Comparative Studies KW - Condom KW - Contraception KW - Contraceptive Methods KW - Correlation Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Italy KW - Mediterranean Countries KW - Neoplasms KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Research Report KW - Retrospective Studies KW - Risk Factors KW - Southern Europe KW - Statistical Studies KW - Studies KW - Vaginal Barrier Methods KW - Vaginal Diaphragm SP - 519 EP - 30 JF - Contraception JO - Contraception VL - 40 IS - 5 N2 - The relationship between the use of barrier contraception methods and the risk of cervical neoplasia was analyzed using data from a case-control study conducted in the greater Milan area, northern Italy. A total of 367 cases of invasive cancer under 60 years of age were compared with 323 subjects in hospital for acute conditions unrelated to any of the established or suspected risk factors for cervical cancer, and 316 cases of cervical intraepithelial neoplasia were compared with 258 outpatient controls. Ever-use of barrier methods (condom and diaphragm) was reported by 6% of the cases of invasive cancer and 12% of hospital controls. Corresponding values for intraepithelial neoplasia were 16% for cases and 22% for outpatient controls. Considering the total use of barrier methods, compared to never use, the relative risk of invasive cervical cancer was 0.4 (95% confidence interval 0.2-0.9) and decreased with duration of use (chi 2(1), trend = 5.18, p = 0.02). Likewise, use of barrier methods lowered the risk of intraepithelial neoplasia; the estimated relative risks were 0.9 in users for less than two years and 0.6 for two or more (chi 2(1), trend = 4.61, p = 0.03). Although the protection for invasive cancer appeared to be greater at older ages and in multiparous women, the relative risks were not significantly heterogeneous in various strata of parity, number of sexual partners, oral contraceptive use and history of Pap smears. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/2692961/Barrier_methods_of_contraception_and_the_risk_of_cervical_neoplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(89)90125-X DB - PRIME DP - Unbound Medicine ER -