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The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia.
Wien Klin Wochenschr. 2016 May; 128(9-10):335-40.WK

Abstract

BACKGROUND AND AIM

The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection.

METHODS

The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits.

RESULTS

There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001).

CONCLUSION

Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.

Authors+Show Affiliations

Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey. ferda-sapmaz@hotmail.com.Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey.Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.Department of Biochemistry, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

26932797

Citation

Sapmaz, Ferdane, et al. "The Impact of Helicobacter Pylori Eradication On Serum Hepcidin-25 Level and Iron Parameters in Patients With Iron Deficiency Anemia." Wiener Klinische Wochenschrift, vol. 128, no. 9-10, 2016, pp. 335-40.
Sapmaz F, Başyiğit S, Kalkan İH, et al. The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia. Wien Klin Wochenschr. 2016;128(9-10):335-40.
Sapmaz, F., Başyiğit, S., Kalkan, İ. H., Kısa, Ü., Kavak, E. E., & Güliter, S. (2016). The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia. Wiener Klinische Wochenschrift, 128(9-10), 335-40. https://doi.org/10.1007/s00508-016-0961-5
Sapmaz F, et al. The Impact of Helicobacter Pylori Eradication On Serum Hepcidin-25 Level and Iron Parameters in Patients With Iron Deficiency Anemia. Wien Klin Wochenschr. 2016;128(9-10):335-40. PubMed PMID: 26932797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia. AU - Sapmaz,Ferdane, AU - Başyiğit,Sebahat, AU - Kalkan,İsmail Hakkı, AU - Kısa,Üçler, AU - Kavak,Engin Eren, AU - Güliter,Sefa, Y1 - 2016/03/01/ PY - 2015/06/01/received PY - 2016/01/21/accepted PY - 2016/3/3/entrez PY - 2016/3/5/pubmed PY - 2017/5/6/medline SP - 335 EP - 40 JF - Wiener klinische Wochenschrift JO - Wien Klin Wochenschr VL - 128 IS - 9-10 N2 - BACKGROUND AND AIM: The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection. METHODS: The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits. RESULTS: There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001). CONCLUSION: Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA. SN - 1613-7671 UR - https://www.unboundmedicine.com/medline/citation/26932797/The_impact_of_Helicobacter_pylori_eradication_on_serum_hepcidin_25_level_and_iron_parameters_in_patients_with_iron_deficiency_anemia_ L2 - https://dx.doi.org/10.1007/s00508-016-0961-5 DB - PRIME DP - Unbound Medicine ER -