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Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood.
Proc Nutr Soc 2016; 75(2):115-24PN

Abstract

Obesity-related metabolic conditions such as insulin resistance (IR), type 2 diabetes and CVD share a number of pathological features, one of which is metabolic-inflammation. Metabolic-inflammation results from the infiltration of immune cells into the adipose tissue, driving a pro-inflammatory environment, which can induce IR. Furthermore, resolution of inflammation, an active process wherein the immune system counteracts pro-inflammatory states, may be dysregulated in obesity. Anti-inflammatory nutritional interventions have focused on attenuating this pro-inflammatory environment. Furthermore, with inherent variability among individuals, establishing at-risk populations who respond favourably to nutritional intervention strategies is important. This review will focus on chronic low-grade metabolic-inflammation, resolution of inflammation and the putative role anti-inflammatory nutrients have as a potential therapy. Finally, in the context of personalised nutrition, the approaches used in defining individuals who respond favourably to nutritional interventions will be highlighted. With increasing prevalence of obesity in younger people, age-dependent biological processes, preventative strategies and therapeutic options are important to help protect against development of obesity-associated co-morbidities.

Authors+Show Affiliations

Nutrigenomics Research Group,UCD Conway Institute,School of Public Health and Population Science,University College Dublin,Dublin 4,Republic of Ireland.Nutrigenomics Research Group,UCD Conway Institute,School of Public Health and Population Science,University College Dublin,Dublin 4,Republic of Ireland.Diabetes Complications Research Centre,UCD Conway Institute and School of Medicine,University College Dublin,Dublin 4,Republic of Ireland.School of Medicine,Trinity College Dublin,Trinity for Health Sciences,St. James's Hospital,Dublin 8,Republic of Ireland.Nutrigenomics Research Group,UCD Conway Institute,School of Public Health and Population Science,University College Dublin,Dublin 4,Republic of Ireland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26934951

Citation

Connaughton, Ruth M., et al. "Impact of Anti-inflammatory Nutrients On Obesity-associated Metabolic-inflammation From Childhood Through to Adulthood." The Proceedings of the Nutrition Society, vol. 75, no. 2, 2016, pp. 115-24.
Connaughton RM, McMorrow AM, McGillicuddy FC, et al. Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. Proc Nutr Soc. 2016;75(2):115-24.
Connaughton, R. M., McMorrow, A. M., McGillicuddy, F. C., Lithander, F. E., & Roche, H. M. (2016). Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. The Proceedings of the Nutrition Society, 75(2), pp. 115-24. doi:10.1017/S0029665116000070.
Connaughton RM, et al. Impact of Anti-inflammatory Nutrients On Obesity-associated Metabolic-inflammation From Childhood Through to Adulthood. Proc Nutr Soc. 2016;75(2):115-24. PubMed PMID: 26934951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. AU - Connaughton,Ruth M, AU - McMorrow,Aoibheann M, AU - McGillicuddy,Fiona C, AU - Lithander,Fiona E, AU - Roche,Helen M, Y1 - 2016/03/03/ PY - 2016/3/4/entrez PY - 2016/3/5/pubmed PY - 2017/1/4/medline KW - AT adipose tissue KW - Anti-inflammatory nutrients KW - CRP C-reactive protein KW - IKK IκB kinase KW - IR insulin resistance KW - IRS insulin receptor substrate KW - JNK c-Jun N-Terminal kinase KW - LC n-3 PUFA long chain n-3 PUFA KW - LPS lipopolysaccharide KW - MetS metabolic syndrome KW - Metabolic health KW - NLR nod-like receptor KW - Obesity KW - T2D type 2 diabetes KW - TLR toll-like receptor SP - 115 EP - 24 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 75 IS - 2 N2 - Obesity-related metabolic conditions such as insulin resistance (IR), type 2 diabetes and CVD share a number of pathological features, one of which is metabolic-inflammation. Metabolic-inflammation results from the infiltration of immune cells into the adipose tissue, driving a pro-inflammatory environment, which can induce IR. Furthermore, resolution of inflammation, an active process wherein the immune system counteracts pro-inflammatory states, may be dysregulated in obesity. Anti-inflammatory nutritional interventions have focused on attenuating this pro-inflammatory environment. Furthermore, with inherent variability among individuals, establishing at-risk populations who respond favourably to nutritional intervention strategies is important. This review will focus on chronic low-grade metabolic-inflammation, resolution of inflammation and the putative role anti-inflammatory nutrients have as a potential therapy. Finally, in the context of personalised nutrition, the approaches used in defining individuals who respond favourably to nutritional interventions will be highlighted. With increasing prevalence of obesity in younger people, age-dependent biological processes, preventative strategies and therapeutic options are important to help protect against development of obesity-associated co-morbidities. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/26934951/Impact_of_anti_inflammatory_nutrients_on_obesity_associated_metabolic_inflammation_from_childhood_through_to_adulthood_ L2 - https://www.cambridge.org/core/product/identifier/S0029665116000070/type/journal_article DB - PRIME DP - Unbound Medicine ER -