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EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn.
Influenza Other Respir Viruses. 2016 May; 10(3):154-60.IO

Abstract

BACKGROUND

Human enterovirus D68 (EV-D68) recently caused an increase in mild-to-severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed.

OBJECTIVES

The purposes of this report were to describe the clinical findings of an outbreak of EV-D68 infection in Mexico City and identify the genetic relationship with previously reported strains.

PATIENTS/METHODS

Between September and December 2014, 126 nasopharyngeal samples (NPS) of hospitalized children <15 years of age with ARI were tested for the presence of respiratory viruses using a multiplex RT-qPCR and EV-D68-specific RT-qPCR. Clinical, epidemiological, and demographic data were collected and associated with symptomatology and viral infections. Phylogenetic analyses were performed using VP1 region.

RESULTS

Enterovirus/rhinovirus infection was detected in 40 patients (31·7%), of which 24 patients were EV-D68-positive. EV-D68 infection prevailed over September and October 2014 and was associated with neutrophilia and lymphopenia, and patients were more likely to develop hypoxemia. Phylogenetic analyses showed that Mexican EV-D68 belongs to the new B1 clade.

CONCLUSIONS

This is the first EV-D68 outbreak described in Mexico and occurred few weeks after the United States reported similar infections. Although EV-D68 belongs to new B1 clade, no neurological affection was observed.

Authors+Show Affiliations

Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto de Diagnostico y Referencia Epidemiologicos, Manuel Martinez Baez, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto de Diagnostico y Referencia Epidemiologicos, Manuel Martinez Baez, Mexico City, Mexico.Instituto de Diagnostico y Referencia Epidemiologicos, Manuel Martinez Baez, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.Instituto de Diagnostico y Referencia Epidemiologicos, Manuel Martinez Baez, Mexico City, Mexico.Instituto de Diagnostico y Referencia Epidemiologicos, Manuel Martinez Baez, Mexico City, Mexico. Facultad de Medicina, UNAM, Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26935868

Citation

Vazquez-Perez, Joel A., et al. "EV-D68 Infection in Children With Asthma Exacerbation and Pneumonia in Mexico City During 2014 Autumn." Influenza and Other Respiratory Viruses, vol. 10, no. 3, 2016, pp. 154-60.
Vazquez-Perez JA, Ramirez-Gonzalez JE, Moreno-Valencia Y, et al. EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn. Influenza Other Respir Viruses. 2016;10(3):154-60.
Vazquez-Perez, J. A., Ramirez-Gonzalez, J. E., Moreno-Valencia, Y., Hernandez-Hernandez, V. A., Romero-Espinoza, J. A., Castillejos-Lopez, M., Hernandez, A., Perez-Padilla, R., Oropeza-Lopez, L. E., Escobar-Escamilla, N., Gonzalez-Villa, M., Alejandre-Garcia, A., Regalado-Pineda, J., Santillan-Doherty, P., Lopez-Martínez, I., Diaz-Quiñonez, A., & Salas-Hernandez, J. (2016). EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn. Influenza and Other Respiratory Viruses, 10(3), 154-60. https://doi.org/10.1111/irv.12384
Vazquez-Perez JA, et al. EV-D68 Infection in Children With Asthma Exacerbation and Pneumonia in Mexico City During 2014 Autumn. Influenza Other Respir Viruses. 2016;10(3):154-60. PubMed PMID: 26935868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn. AU - Vazquez-Perez,Joel A, AU - Ramirez-Gonzalez,Jose E, AU - Moreno-Valencia,Yazmin, AU - Hernandez-Hernandez,Victor A, AU - Romero-Espinoza,Jose A I, AU - Castillejos-Lopez,Manuel, AU - Hernandez,Andres, AU - Perez-Padilla,Rogelio, AU - Oropeza-Lopez,Lizbeth E, AU - Escobar-Escamilla,Noe, AU - Gonzalez-Villa,Maribel, AU - Alejandre-Garcia,Alejandro, AU - Regalado-Pineda,Justino, AU - Santillan-Doherty,Patricio, AU - Lopez-Martínez,Irma, AU - Diaz-Quiñonez,Alberto, AU - Salas-Hernandez,Jorge, PY - 2016/02/24/accepted PY - 2016/3/4/entrez PY - 2016/3/5/pubmed PY - 2016/12/20/medline KW - Enterovirus D68 KW - epidemiology KW - outbreak KW - pediatric KW - respiratory viruses SP - 154 EP - 60 JF - Influenza and other respiratory viruses JO - Influenza Other Respir Viruses VL - 10 IS - 3 N2 - BACKGROUND: Human enterovirus D68 (EV-D68) recently caused an increase in mild-to-severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed. OBJECTIVES: The purposes of this report were to describe the clinical findings of an outbreak of EV-D68 infection in Mexico City and identify the genetic relationship with previously reported strains. PATIENTS/METHODS: Between September and December 2014, 126 nasopharyngeal samples (NPS) of hospitalized children <15 years of age with ARI were tested for the presence of respiratory viruses using a multiplex RT-qPCR and EV-D68-specific RT-qPCR. Clinical, epidemiological, and demographic data were collected and associated with symptomatology and viral infections. Phylogenetic analyses were performed using VP1 region. RESULTS: Enterovirus/rhinovirus infection was detected in 40 patients (31·7%), of which 24 patients were EV-D68-positive. EV-D68 infection prevailed over September and October 2014 and was associated with neutrophilia and lymphopenia, and patients were more likely to develop hypoxemia. Phylogenetic analyses showed that Mexican EV-D68 belongs to the new B1 clade. CONCLUSIONS: This is the first EV-D68 outbreak described in Mexico and occurred few weeks after the United States reported similar infections. Although EV-D68 belongs to new B1 clade, no neurological affection was observed. SN - 1750-2659 UR - https://www.unboundmedicine.com/medline/citation/26935868/EV_D68_infection_in_children_with_asthma_exacerbation_and_pneumonia_in_Mexico_City_during_2014_autumn_ L2 - https://doi.org/10.1111/irv.12384 DB - PRIME DP - Unbound Medicine ER -