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The impact of diabetes and other metabolic disorders on prostate cancer prognosis.
J Diabetes Complications 2016 May-Jun; 30(4):591-6JD

Abstract

AIMS

To investigate the impact of diabetes mellitus (DM) and other metabolic disorders on the survival of men with prostate cancer (PCa).

METHODS

We conducted a retrospective cohort-study based on 715 men with PCa, originally enrolled in an Italian case-control study between 1995 and 2002. Anthropometric measures, self-reported medical conditions, and Gleason score were assessed at enrollment. Adjusted hazard ratios (HRs) of death, with 95% confidence intervals (95% CIs), were estimated using Fine and Gray's regression model.

RESULTS

After a median follow-up of 11.6years, 244 (34.1%) deaths occurred, 77 (31.6%) due to PCa. Excess mortality from all causes was reported in PCa patients with DM (HR=1.56, 95% CI: 1.03-2.36), which increased to 1.76 (95% CI: 0.99-3.13) when at least two out of three metabolic disorders (i.e., waist circumference ≥102cm, drug-treated hypertension, and hypercholesterolemia) were additionally present. The impact of metabolic disorders was stronger on non-PCa-specific mortality with HRs equal to 2.21 (95% CI: 1.38-3.54) for DM, 1.45 (95% CI: 0.97-2.19) for waist circumference ≥102cm, and 1.63 (95% CI: 1.19-2.22) for drug-treated hypertension.

CONCLUSIONS

DM and other metabolic disorders unfavorably affected the survival of PCa patients, mainly impacting on the risk of death from causes other than PCa.

Authors+Show Affiliations

Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: polesel@cro.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: agini@cro.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: dalmaso@cro.it.Venetian Cancer Registry, Istituto Oncologico Veneto, Passaggio Gaudenzio 1, 35131 Padua (PD), Italy. Electronic address: carmen.stocco@ioveneto.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: birris@cro.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: mtaborelli@cro.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: serrainod@cro.it.Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano (PN), Italy. Electronic address: zucchetto.epi@cro.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26936307

Citation

Polesel, Jerry, et al. "The Impact of Diabetes and Other Metabolic Disorders On Prostate Cancer Prognosis." Journal of Diabetes and Its Complications, vol. 30, no. 4, 2016, pp. 591-6.
Polesel J, Gini A, Dal Maso L, et al. The impact of diabetes and other metabolic disorders on prostate cancer prognosis. J Diabetes Complicat. 2016;30(4):591-6.
Polesel, J., Gini, A., Dal Maso, L., Stocco, C., Birri, S., Taborelli, M., ... Zucchetto, A. (2016). The impact of diabetes and other metabolic disorders on prostate cancer prognosis. Journal of Diabetes and Its Complications, 30(4), pp. 591-6. doi:10.1016/j.jdiacomp.2016.02.008.
Polesel J, et al. The Impact of Diabetes and Other Metabolic Disorders On Prostate Cancer Prognosis. J Diabetes Complicat. 2016;30(4):591-6. PubMed PMID: 26936307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of diabetes and other metabolic disorders on prostate cancer prognosis. AU - Polesel,Jerry, AU - Gini,Andrea, AU - Dal Maso,Luigino, AU - Stocco,Carmen, AU - Birri,Silvia, AU - Taborelli,Martina, AU - Serraino,Diego, AU - Zucchetto,Antonella, Y1 - 2016/02/09/ PY - 2015/11/10/received PY - 2016/01/29/revised PY - 2016/02/07/accepted PY - 2016/3/4/entrez PY - 2016/3/5/pubmed PY - 2017/1/17/medline KW - Diabetes mellitus KW - Metabolic disorders KW - Obesity KW - Prostate cancer KW - Survival SP - 591 EP - 6 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 30 IS - 4 N2 - AIMS: To investigate the impact of diabetes mellitus (DM) and other metabolic disorders on the survival of men with prostate cancer (PCa). METHODS: We conducted a retrospective cohort-study based on 715 men with PCa, originally enrolled in an Italian case-control study between 1995 and 2002. Anthropometric measures, self-reported medical conditions, and Gleason score were assessed at enrollment. Adjusted hazard ratios (HRs) of death, with 95% confidence intervals (95% CIs), were estimated using Fine and Gray's regression model. RESULTS: After a median follow-up of 11.6years, 244 (34.1%) deaths occurred, 77 (31.6%) due to PCa. Excess mortality from all causes was reported in PCa patients with DM (HR=1.56, 95% CI: 1.03-2.36), which increased to 1.76 (95% CI: 0.99-3.13) when at least two out of three metabolic disorders (i.e., waist circumference ≥102cm, drug-treated hypertension, and hypercholesterolemia) were additionally present. The impact of metabolic disorders was stronger on non-PCa-specific mortality with HRs equal to 2.21 (95% CI: 1.38-3.54) for DM, 1.45 (95% CI: 0.97-2.19) for waist circumference ≥102cm, and 1.63 (95% CI: 1.19-2.22) for drug-treated hypertension. CONCLUSIONS: DM and other metabolic disorders unfavorably affected the survival of PCa patients, mainly impacting on the risk of death from causes other than PCa. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/26936307/The_impact_of_diabetes_and_other_metabolic_disorders_on_prostate_cancer_prognosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(16)00059-3 DB - PRIME DP - Unbound Medicine ER -