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Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhoea in a Young Man.
Case Rep Med. 2016; 2016:4210397.CR

Abstract

A young Indian man presented with nine-month history of chronic diarrhea, occasionally mixed with blood and intermittent colicky abdominal pain. He also complained of generalized body swelling for the last three months. On examination, he had diffuse hyperpigmentation of the skin and dystrophic nail changes. Upper and lower gastrointestinal endoscopy revealed multiple sessile polyps in the stomach, small bowel, and colon and rectum. Biopsy of polyps showed adenomatous changes with stromal edema and dilated glands. Cronkhite-Canada syndrome (CCS) was diagnosed and treated with glucocorticoids and enteral nutritional supplementation. There was an associated small intestinal bacterial overgrowth (SIBO) and stool was positive for clostridium difficile toxin. After 12 weeks of treatment, the patient achieved remission. Close correlation with clinical findings, including pertinent ectodermal abnormalities, endoscopic studies, and careful examination of biopsies will ensure a timely and correct diagnosis of CCS.

Authors+Show Affiliations

Department of Accident and Emergency, Lady Hardinge Medical College, New Delhi, India.Department of Internal Medicine, IPGMER, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.Lady Hardinge Medical College, New Delhi, India.R. G. Kar Medical College, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26941798

Citation

Bandyopadhyay, Dhrubajyoti, et al. "Cronkhite-Canada Syndrome: a Rare Cause of Chronic Diarrhoea in a Young Man." Case Reports in Medicine, vol. 2016, 2016, p. 4210397.
Bandyopadhyay D, Hajra A, Ganesan V, et al. Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhoea in a Young Man. Case Rep Med. 2016;2016:4210397.
Bandyopadhyay, D., Hajra, A., Ganesan, V., Kar, S. S., Bhar, D., Layek, M., Mukhopadhyay, S., Choudhury, C., Choudhary, V., & Banerjee, P. (2016). Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhoea in a Young Man. Case Reports in Medicine, 2016, 4210397. https://doi.org/10.1155/2016/4210397
Bandyopadhyay D, et al. Cronkhite-Canada Syndrome: a Rare Cause of Chronic Diarrhoea in a Young Man. Case Rep Med. 2016;2016:4210397. PubMed PMID: 26941798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhoea in a Young Man. AU - Bandyopadhyay,Dhrubajyoti, AU - Hajra,Adrija, AU - Ganesan,Vijayan, AU - Kar,Suvrendu Sankar, AU - Bhar,Debarati, AU - Layek,Manas, AU - Mukhopadhyay,Sabyasachi, AU - Choudhury,Cankatika, AU - Choudhary,Vivek, AU - Banerjee,Prasun, Y1 - 2016/01/28/ PY - 2015/10/22/received PY - 2016/01/11/accepted PY - 2016/3/5/entrez PY - 2016/3/5/pubmed PY - 2016/3/5/medline SP - 4210397 EP - 4210397 JF - Case reports in medicine JO - Case Rep Med VL - 2016 N2 - A young Indian man presented with nine-month history of chronic diarrhea, occasionally mixed with blood and intermittent colicky abdominal pain. He also complained of generalized body swelling for the last three months. On examination, he had diffuse hyperpigmentation of the skin and dystrophic nail changes. Upper and lower gastrointestinal endoscopy revealed multiple sessile polyps in the stomach, small bowel, and colon and rectum. Biopsy of polyps showed adenomatous changes with stromal edema and dilated glands. Cronkhite-Canada syndrome (CCS) was diagnosed and treated with glucocorticoids and enteral nutritional supplementation. There was an associated small intestinal bacterial overgrowth (SIBO) and stool was positive for clostridium difficile toxin. After 12 weeks of treatment, the patient achieved remission. Close correlation with clinical findings, including pertinent ectodermal abnormalities, endoscopic studies, and careful examination of biopsies will ensure a timely and correct diagnosis of CCS. SN - 1687-9627 UR - https://www.unboundmedicine.com/medline/citation/26941798/Cronkhite_Canada_Syndrome:_A_Rare_Cause_of_Chronic_Diarrhoea_in_a_Young_Man_ L2 - https://dx.doi.org/10.1155/2016/4210397 DB - PRIME DP - Unbound Medicine ER -
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