Tags

Type your tag names separated by a space and hit enter

Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis.
Dig Dis Sci 2016; 61(5):1387-97DD

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in the USA with a growing prevalence worldwide. Nonalcoholic steatohepatitis (NASH), progressive form of NAFLD, can lead to the development of cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. Treatment of NASH may decrease the risk of progressive disease. Treatment for NAFLD should center around weight loss and exercise. Pharmacotherapy with vitamin E and pioglitazone should be considered for those with NASH, especially those with fibrosis. Weight loss surgery is also an effective treatment for NASH in individuals with other indications for surgery. In this review, we will discuss the currently available therapies for NASH including lifestyle, pharmacologic, and surgical options.

Authors+Show Affiliations

Gastrointestinal Unit, Liver Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. kcorey@partners.org. Department of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. kcorey@partners.org.Gastrointestinal Unit, Liver Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Department of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26942734

Citation

Corey, Kathleen E., and Mary E. Rinella. "Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis." Digestive Diseases and Sciences, vol. 61, no. 5, 2016, pp. 1387-97.
Corey KE, Rinella ME. Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis. Dig Dis Sci. 2016;61(5):1387-97.
Corey, K. E., & Rinella, M. E. (2016). Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis. Digestive Diseases and Sciences, 61(5), pp. 1387-97. doi:10.1007/s10620-016-4083-8.
Corey KE, Rinella ME. Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis. Dig Dis Sci. 2016;61(5):1387-97. PubMed PMID: 26942734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis. AU - Corey,Kathleen E, AU - Rinella,Mary E, Y1 - 2016/03/04/ PY - 2015/12/09/received PY - 2016/02/05/accepted PY - 2016/3/5/entrez PY - 2016/3/5/pubmed PY - 2016/8/26/medline KW - Nonalcoholic fatty liver disease KW - Nonalcoholic steatohepatitis KW - Pioglitazone KW - Vitamin E KW - Weight loss surgery SP - 1387 EP - 97 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 61 IS - 5 N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in the USA with a growing prevalence worldwide. Nonalcoholic steatohepatitis (NASH), progressive form of NAFLD, can lead to the development of cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. Treatment of NASH may decrease the risk of progressive disease. Treatment for NAFLD should center around weight loss and exercise. Pharmacotherapy with vitamin E and pioglitazone should be considered for those with NASH, especially those with fibrosis. Weight loss surgery is also an effective treatment for NASH in individuals with other indications for surgery. In this review, we will discuss the currently available therapies for NASH including lifestyle, pharmacologic, and surgical options. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/26942734/Medical_and_Surgical_Treatment_Options_for_Nonalcoholic_Steatohepatitis_ L2 - https://doi.org/10.1007/s10620-016-4083-8 DB - PRIME DP - Unbound Medicine ER -