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Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Chem Biol Interact. 2016 Apr 25; 250:38-46.CB

Abstract

Diabetes mellitus is a clinically complex disease characterized by chronic hyperglycemia with metabolic disturbances. During diabetes, endogenous hepatic glucose production is increased as a result of impaired activities of the key enzymes of carbohydrate metabolism. The purpose of the present study was to evaluate the antidiabetic efficacy of citronellol, a citrus monoterpene in streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of STZ (40 mg/kg b.w). STZ induced diabetic rats received citronellol orally at the doses of 25, 50, and 100 mg/kg b.w for 30 days. In this study the levels of plasma glucose, insulin, hemoglobin (Hb), glycated hemoglobin (HbA1C), glycogen, and the activities of carbohydrate metabolic enzymes, liver and kidney markers were evaluated. Oral administration of citronellol (50 mg/kg) for 30 days dose dependently improved the levels of insulin, Hb and hepatic glycogen with significant decrease in glucose and HbA1C levels. The altered activities of carbohydrate metabolic enzymes, hepatic and kidney markers were restored to near normal. Citronellol supplement was found to be effective in preserving the normal histological appearance of hepatic cells and insulin-positive β-cells in STZ-rats. Our results suggest that administration of citronellol attenuates the hyperglycemia in the STZ-induced diabetic rats by ameliorating the key carbohydrate metabolic enzymes and could be developed as a functional and nutraceutical ingredient in combating diabetes mellitus.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamilnadu, India. Electronic address: sivaseenu77@gmail.com.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamilnadu, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26944432

Citation

Srinivasan, Subramani, and Udaiyar Muruganathan. "Antidiabetic Efficacy of Citronellol, a Citrus Monoterpene By Ameliorating the Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats." Chemico-biological Interactions, vol. 250, 2016, pp. 38-46.
Srinivasan S, Muruganathan U. Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Chem Biol Interact. 2016;250:38-46.
Srinivasan, S., & Muruganathan, U. (2016). Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Chemico-biological Interactions, 250, 38-46. https://doi.org/10.1016/j.cbi.2016.02.020
Srinivasan S, Muruganathan U. Antidiabetic Efficacy of Citronellol, a Citrus Monoterpene By Ameliorating the Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats. Chem Biol Interact. 2016 Apr 25;250:38-46. PubMed PMID: 26944432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. AU - Srinivasan,Subramani, AU - Muruganathan,Udaiyar, Y1 - 2016/03/02/ PY - 2015/10/08/received PY - 2016/02/01/revised PY - 2016/02/26/accepted PY - 2016/3/6/entrez PY - 2016/3/6/pubmed PY - 2016/8/18/medline KW - Citronellol KW - Diabetes mellitus KW - Glucose KW - Insulin KW - Streptozotocin SP - 38 EP - 46 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 250 N2 - Diabetes mellitus is a clinically complex disease characterized by chronic hyperglycemia with metabolic disturbances. During diabetes, endogenous hepatic glucose production is increased as a result of impaired activities of the key enzymes of carbohydrate metabolism. The purpose of the present study was to evaluate the antidiabetic efficacy of citronellol, a citrus monoterpene in streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of STZ (40 mg/kg b.w). STZ induced diabetic rats received citronellol orally at the doses of 25, 50, and 100 mg/kg b.w for 30 days. In this study the levels of plasma glucose, insulin, hemoglobin (Hb), glycated hemoglobin (HbA1C), glycogen, and the activities of carbohydrate metabolic enzymes, liver and kidney markers were evaluated. Oral administration of citronellol (50 mg/kg) for 30 days dose dependently improved the levels of insulin, Hb and hepatic glycogen with significant decrease in glucose and HbA1C levels. The altered activities of carbohydrate metabolic enzymes, hepatic and kidney markers were restored to near normal. Citronellol supplement was found to be effective in preserving the normal histological appearance of hepatic cells and insulin-positive β-cells in STZ-rats. Our results suggest that administration of citronellol attenuates the hyperglycemia in the STZ-induced diabetic rats by ameliorating the key carbohydrate metabolic enzymes and could be developed as a functional and nutraceutical ingredient in combating diabetes mellitus. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/26944432/Antidiabetic_efficacy_of_citronellol_a_citrus_monoterpene_by_ameliorating_the_hepatic_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(16)30056-4 DB - PRIME DP - Unbound Medicine ER -