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Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations.
Ann N Y Acad Sci 2016; 1374(1):29-40AN

Abstract

Hydrogen sulfide (H2 S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2 S exerts its toxicity through its high affinity with metalloproteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2 S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electromechanical dissociation of the heart. In addition, long-term neurological deficits can develop owing to the direct toxicity of H2 S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2 S intoxication using agents that trap free H2 S, and present novel pharmacological approaches aimed at correcting some of the most harmful consequences of H2 S intoxication.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.Heart and Vascular Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26945701

Citation

Haouzi, Philippe, et al. "Developing Effective Countermeasures Against Acute Hydrogen Sulfide Intoxication: Challenges and Limitations." Annals of the New York Academy of Sciences, vol. 1374, no. 1, 2016, pp. 29-40.
Haouzi P, Sonobe T, Judenherc-Haouzi A. Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. Ann N Y Acad Sci. 2016;1374(1):29-40.
Haouzi, P., Sonobe, T., & Judenherc-Haouzi, A. (2016). Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. Annals of the New York Academy of Sciences, 1374(1), pp. 29-40. doi:10.1111/nyas.13015.
Haouzi P, Sonobe T, Judenherc-Haouzi A. Developing Effective Countermeasures Against Acute Hydrogen Sulfide Intoxication: Challenges and Limitations. Ann N Y Acad Sci. 2016;1374(1):29-40. PubMed PMID: 26945701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. AU - Haouzi,Philippe, AU - Sonobe,Takashi, AU - Judenherc-Haouzi,Annick, Y1 - 2016/03/04/ PY - 2015/11/16/received PY - 2015/12/25/revised PY - 2016/01/11/accepted PY - 2016/3/7/entrez PY - 2016/3/8/pubmed PY - 2017/8/2/medline KW - H2S KW - apnea KW - hydrogen sulfide KW - hydroxocobalamin KW - methemoglobin KW - methylene blue KW - pulseless electrical activity SP - 29 EP - 40 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1374 IS - 1 N2 - Hydrogen sulfide (H2 S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2 S exerts its toxicity through its high affinity with metalloproteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2 S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electromechanical dissociation of the heart. In addition, long-term neurological deficits can develop owing to the direct toxicity of H2 S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2 S intoxication using agents that trap free H2 S, and present novel pharmacological approaches aimed at correcting some of the most harmful consequences of H2 S intoxication. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/26945701/Developing_effective_countermeasures_against_acute_hydrogen_sulfide_intoxication:_challenges_and_limitations_ L2 - https://doi.org/10.1111/nyas.13015 DB - PRIME DP - Unbound Medicine ER -