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The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block.
Anaesthesia. 2016 06; 71(6):700-5.A

Abstract

The aim of this study was to determine the minimum effective concentration of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Fifty-one patients undergoing arm surgery received double-injection ultrasound-guided supraclavicular block using ropivacaine 40 ml. The concentration of ropivacaine administered to each patient started at 0.225% and then depended on the response of the previous one, based on a biased coin design up-and-down sequential method. In case of failure, the ropivacaine concentration was increased by 0.025% w/v in the next subject. In the case of a successful block, the next patient was randomised to the same concentration or a concentration 0.025% w/v less. Success was defined as complete sensory blockade of the brachial plexus 30 min after the block together with pain-free surgery. The minimum effective ropivacaine concentration in 90% of subjects was 0.257% w/v (95% CI 0.241-0.280%).

Authors+Show Affiliations

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26945818

Citation

Fang, G, et al. "The Minimum Effective Concentration (MEC90) of Ropivacaine for Ultrasound-guided Supraclavicular Brachial Plexus Block." Anaesthesia, vol. 71, no. 6, 2016, pp. 700-5.
Fang G, Wan L, Mei W, et al. The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Anaesthesia. 2016;71(6):700-5.
Fang, G., Wan, L., Mei, W., Yu, H. H., & Luo, A. L. (2016). The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Anaesthesia, 71(6), 700-5. https://doi.org/10.1111/anae.13445
Fang G, et al. The Minimum Effective Concentration (MEC90) of Ropivacaine for Ultrasound-guided Supraclavicular Brachial Plexus Block. Anaesthesia. 2016;71(6):700-5. PubMed PMID: 26945818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. AU - Fang,G, AU - Wan,L, AU - Mei,W, AU - Yu,H H, AU - Luo,A L, Y1 - 2016/03/04/ PY - 2016/02/08/accepted PY - 2016/3/7/entrez PY - 2016/3/8/pubmed PY - 2018/8/28/medline KW - brachial plexus block KW - local anaesthetic KW - minimum effective concentration KW - peripheral nerve block KW - ropivacaine KW - supraclavicular approach KW - ultrasound guidance SP - 700 EP - 5 JF - Anaesthesia JO - Anaesthesia VL - 71 IS - 6 N2 - The aim of this study was to determine the minimum effective concentration of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Fifty-one patients undergoing arm surgery received double-injection ultrasound-guided supraclavicular block using ropivacaine 40 ml. The concentration of ropivacaine administered to each patient started at 0.225% and then depended on the response of the previous one, based on a biased coin design up-and-down sequential method. In case of failure, the ropivacaine concentration was increased by 0.025% w/v in the next subject. In the case of a successful block, the next patient was randomised to the same concentration or a concentration 0.025% w/v less. Success was defined as complete sensory blockade of the brachial plexus 30 min after the block together with pain-free surgery. The minimum effective ropivacaine concentration in 90% of subjects was 0.257% w/v (95% CI 0.241-0.280%). SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/26945818/The_minimum_effective_concentration__MEC90__of_ropivacaine_for_ultrasound_guided_supraclavicular_brachial_plexus_block_ L2 - https://doi.org/10.1111/anae.13445 DB - PRIME DP - Unbound Medicine ER -