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Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study.
Br J Nutr. 2016 05; 115(9):1607-15.BJ

Abstract

We evaluated the relationship between urine concentrations of phyto-oestrogens (isoflavones and lignans) and risk of incident type 2 diabetes in middle-aged and elderly Chinese residing in Singapore. Urine metabolites of isoflavones and lignans were assayed by HPLC among 564 diabetes cases and 564 matched controls in a case-control study nested within the Singapore Chinese Health Study cohort. Participants were free of diagnosed diabetes, CVD and cancer at morning urine collections during 1999-2004. Cases were participants who reported to have physician-diagnosed diabetes at follow-up visits during 2006-2010, whereas controls were randomly selected among those who remained free of diabetes and were matched to the index cases by age, sex, dialect group and date of urine collection. Conditional logistic regression models were used to calculate OR and 95 % CI with adjustment for potential confounders. The mean age of the participants at the time of urine collection was 59·8 years, and the average interval between urine collection and diabetes diagnosis was 4·0 years. The multivariate-adjusted OR for diabetes were 1·00 (reference), 0·76 (95 % CI 0·52, 1·11), 0·78 (95 % CI 0·53, 1·14) and 0·79 (95 % CI 0·54, 1·15) across quartiles of urine isoflavones (P for trend=0·54), and were 1·00 (reference), 0·87 (95 % CI 0·60, 1·27), 1·10 (95 % CI 0·77, 1·56) and 0·93 (95 % CI 0·63, 1·37) for lignans (P for trend=0·93). The results were similar in men and women, as well as for individual metabolites of isoflavones (genistein, daidzein, glycitin and equol) or lignans (enterodiol and enterolactone). The present study did not find a significant association between urine phyto-oestrogen metabolites and risk of type 2 diabetes in Chinese adults.

Authors+Show Affiliations

1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.1Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,Singapore 117549,Singapore.4Division of Cancer Control and Population Sciences,University of Pittsburgh Cancer Institute,Pittsburgh,PA 15232,USA.6Duke-NUS Graduate Medical School,Singapore 169857,Singapore.7Department of Epidemiology and Biostatistics,MOE Key Laboratory of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26949260

Citation

Talaei, Mohammad, et al. "Urine Phyto-oestrogen Metabolites Are Not Significantly Associated With Risk of Type 2 Diabetes: the Singapore Chinese Health Study." The British Journal of Nutrition, vol. 115, no. 9, 2016, pp. 1607-15.
Talaei M, Lee BL, Ong CN, et al. Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study. Br J Nutr. 2016;115(9):1607-15.
Talaei, M., Lee, B. L., Ong, C. N., van Dam, R. M., Yuan, J. M., Koh, W. P., & Pan, A. (2016). Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study. The British Journal of Nutrition, 115(9), 1607-15. https://doi.org/10.1017/S0007114516000581
Talaei M, et al. Urine Phyto-oestrogen Metabolites Are Not Significantly Associated With Risk of Type 2 Diabetes: the Singapore Chinese Health Study. Br J Nutr. 2016;115(9):1607-15. PubMed PMID: 26949260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study. AU - Talaei,Mohammad, AU - Lee,Bee L, AU - Ong,Choon N, AU - van Dam,Rob M, AU - Yuan,Jian M, AU - Koh,Woon P, AU - Pan,An, Y1 - 2016/03/07/ PY - 2016/3/8/entrez PY - 2016/3/8/pubmed PY - 2017/5/6/medline KW - CRP C-reactive protein KW - Incidence KW - Isoflavones KW - Lignans KW - NHS Nurse’s Health Study KW - SCHS Singapore Chinese Health Study KW - T2D type 2 diabetes KW - Type 2 diabetes KW - Urine metabolites SP - 1607 EP - 15 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 9 N2 - We evaluated the relationship between urine concentrations of phyto-oestrogens (isoflavones and lignans) and risk of incident type 2 diabetes in middle-aged and elderly Chinese residing in Singapore. Urine metabolites of isoflavones and lignans were assayed by HPLC among 564 diabetes cases and 564 matched controls in a case-control study nested within the Singapore Chinese Health Study cohort. Participants were free of diagnosed diabetes, CVD and cancer at morning urine collections during 1999-2004. Cases were participants who reported to have physician-diagnosed diabetes at follow-up visits during 2006-2010, whereas controls were randomly selected among those who remained free of diabetes and were matched to the index cases by age, sex, dialect group and date of urine collection. Conditional logistic regression models were used to calculate OR and 95 % CI with adjustment for potential confounders. The mean age of the participants at the time of urine collection was 59·8 years, and the average interval between urine collection and diabetes diagnosis was 4·0 years. The multivariate-adjusted OR for diabetes were 1·00 (reference), 0·76 (95 % CI 0·52, 1·11), 0·78 (95 % CI 0·53, 1·14) and 0·79 (95 % CI 0·54, 1·15) across quartiles of urine isoflavones (P for trend=0·54), and were 1·00 (reference), 0·87 (95 % CI 0·60, 1·27), 1·10 (95 % CI 0·77, 1·56) and 0·93 (95 % CI 0·63, 1·37) for lignans (P for trend=0·93). The results were similar in men and women, as well as for individual metabolites of isoflavones (genistein, daidzein, glycitin and equol) or lignans (enterodiol and enterolactone). The present study did not find a significant association between urine phyto-oestrogen metabolites and risk of type 2 diabetes in Chinese adults. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26949260/Urine_phyto_oestrogen_metabolites_are_not_significantly_associated_with_risk_of_type_2_diabetes:_the_Singapore_Chinese_health_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516000581/type/journal_article DB - PRIME DP - Unbound Medicine ER -