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The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study.
Biomed Res Int 2016; 2016:3627463BR

Abstract

This study aimed to compare the antimicrobial effectiveness of ethanolic extract of propolis (EEP) to chlorhexidine gluconate (CHX) on planktonic Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lactobacillus salivarius subsp. salivarius, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Staphylococcus aureus, Enterococcus faecalis, Actinomyces israelii, Candida albicans, and their single-species biofilms by agar dilution and broth microdilution test methods. Both agents inhibited the growth of all planktonic species. On the other hand, CHX exhibited lower minimum bactericidal concentrations than EEP against biofilms of A. actinomycetemcomitans, S. aureus, and E. faecalis whereas EEP yielded a better result against Lactobacilli and P. intermedia. The bactericidal and fungicidal concentrations of both agents were found to be equal against biofilms of Streptecocci, P. gingivalis, A. israelii, and C. albicans. The results of this study revealed that propolis was more effective in inhibiting Gram-positive bacteria than the Gram-negative bacteria in their planktonic state and it was suggested that EEP could be as effective as CHX on oral microorganisms in their biofilm state.

Authors+Show Affiliations

Faculty of Dentistry, Department of Periodontology, Istanbul Kemerburgaz University, Mahmutbey, 34217 Istanbul, Turkey.Gazi University Faculty of Dentistry, Department of Medical Microbiology, Emek, 06510 Ankara, Turkey.Gulhane Military Medical Academy, Center for Dental Sciences, Department of Restorative Dentistry, Etlik, 06010 Ankara, Turkey.Gulhane Military Medical Academy, Department of Analytical Toxicology, Etlik, 06010 Ankara, Turkey.Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Dentistry, Section of Periodontology, Haydarpasa, 34668 Istanbul, Turkey.Faculty of Dentistry, Department of Oral Surgery, Istanbul Kemerburgaz University, Mahmutbey, 34217 Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26949701

Citation

Akca, A Eralp, et al. "The Comparative Evaluation of the Antimicrobial Effect of Propolis With Chlorhexidine Against Oral Pathogens: an in Vitro Study." BioMed Research International, vol. 2016, 2016, p. 3627463.
Akca AE, Akca G, Topçu FT, et al. The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study. Biomed Res Int. 2016;2016:3627463.
Akca, A. E., Akca, G., Topçu, F. T., Macit, E., Pikdöken, L., & Özgen, I. Ş. (2016). The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study. BioMed Research International, 2016, p. 3627463. doi:10.1155/2016/3627463.
Akca AE, et al. The Comparative Evaluation of the Antimicrobial Effect of Propolis With Chlorhexidine Against Oral Pathogens: an in Vitro Study. Biomed Res Int. 2016;2016:3627463. PubMed PMID: 26949701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study. AU - Akca,A Eralp, AU - Akca,Gülçin, AU - Topçu,Fulya Toksoy, AU - Macit,Enis, AU - Pikdöken,Levent, AU - Özgen,I Şerif, Y1 - 2016/02/02/ PY - 2015/09/27/received PY - 2015/12/07/accepted PY - 2016/3/8/entrez PY - 2016/3/8/pubmed PY - 2016/11/12/medline SP - 3627463 EP - 3627463 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - This study aimed to compare the antimicrobial effectiveness of ethanolic extract of propolis (EEP) to chlorhexidine gluconate (CHX) on planktonic Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lactobacillus salivarius subsp. salivarius, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Staphylococcus aureus, Enterococcus faecalis, Actinomyces israelii, Candida albicans, and their single-species biofilms by agar dilution and broth microdilution test methods. Both agents inhibited the growth of all planktonic species. On the other hand, CHX exhibited lower minimum bactericidal concentrations than EEP against biofilms of A. actinomycetemcomitans, S. aureus, and E. faecalis whereas EEP yielded a better result against Lactobacilli and P. intermedia. The bactericidal and fungicidal concentrations of both agents were found to be equal against biofilms of Streptecocci, P. gingivalis, A. israelii, and C. albicans. The results of this study revealed that propolis was more effective in inhibiting Gram-positive bacteria than the Gram-negative bacteria in their planktonic state and it was suggested that EEP could be as effective as CHX on oral microorganisms in their biofilm state. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26949701/The_Comparative_Evaluation_of_the_Antimicrobial_Effect_of_Propolis_with_Chlorhexidine_against_Oral_Pathogens:_An_In_Vitro_Study_ L2 - https://dx.doi.org/10.1155/2016/3627463 DB - PRIME DP - Unbound Medicine ER -