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Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years.
Nutr Diabetes. 2016 Mar 07; 6:e199.ND

Abstract

OBJECTIVE

There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women, independent of other dietary and lifestyle factors. One unexplored hypothesis for this association is that fructose malabsorption, due to regular consumption of excess free fructose (EFF) and HFCS, contributes to fructose reactivity in the gastrointestinal tract and intestinal in situ formation of enFruAGEs, which once absorbed, travel beyond the intestinal boundaries to other tissues and promote inflammation. In separate studies, the accumulation of advanced glycation end-products has been associated with joint inflammation in RA. Objective of this study was to assess the association between EFF beverages intake and non-age, non-wear and tear-associated arthritis in US young adults.

METHODS

In this cross sectional study of 1209 adults aged 20-30y, (Nutrition and Health Examination Surveys 2003-2006) exposure variables were high EFF beverages, including HFCS sweetened soft drinks, and any combination of HFCS sweetened soft drinks, fruit drinks (FD) and apple juice, referred to as tEFF. Analyses of diet soda and diet FD were included for comparison. The outcome was self-reported arthritis. Rao Scott Ҳ(2) was used for prevalence differences and logistic regression for associations, adjusted for confounders.

RESULTS

Young adults consuming any combination of high EFF beverages (tEFF) ⩾5 times/week (but not diet soda) were three times as likely to have arthritis as non/low consumers (odds ratios=3.01; p⩽0.021; 95% confidence intervals=1.20-7.59), independent of all covariates, including physical activity, other dietary factors, blood glucose and smoking.

CONCLUSION

EFF beverage intake is significantly associated with arthritis in US adults aged 20-30 years, possibly due to the intestinal in situ formation of enFruAGEs.

Authors+Show Affiliations

Molecular Biology, NY Medical College, Valhalla, NY, USA.Department of Medicine, Icahn School of Medicine, New York, NY, USA.Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26950480

Citation

DeChristopher, L R., et al. "Intake of High-fructose Corn Syrup Sweetened Soft Drinks, Fruit Drinks and Apple Juice Is Associated With Prevalent Arthritis in US Adults, Aged 20-30 Years." Nutrition & Diabetes, vol. 6, 2016, pp. e199.
DeChristopher LR, Uribarri J, Tucker KL. Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutr Diabetes. 2016;6:e199.
DeChristopher, L. R., Uribarri, J., & Tucker, K. L. (2016). Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutrition & Diabetes, 6, e199. https://doi.org/10.1038/nutd.2016.7
DeChristopher LR, Uribarri J, Tucker KL. Intake of High-fructose Corn Syrup Sweetened Soft Drinks, Fruit Drinks and Apple Juice Is Associated With Prevalent Arthritis in US Adults, Aged 20-30 Years. Nutr Diabetes. 2016 Mar 7;6:e199. PubMed PMID: 26950480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. AU - DeChristopher,L R, AU - Uribarri,J, AU - Tucker,K L, Y1 - 2016/03/07/ PY - 2015/09/24/received PY - 2015/11/28/revised PY - 2016/01/23/accepted PY - 2016/3/8/entrez PY - 2016/3/8/pubmed PY - 2016/3/8/medline SP - e199 EP - e199 JF - Nutrition & diabetes JO - Nutr Diabetes VL - 6 N2 - OBJECTIVE: There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women, independent of other dietary and lifestyle factors. One unexplored hypothesis for this association is that fructose malabsorption, due to regular consumption of excess free fructose (EFF) and HFCS, contributes to fructose reactivity in the gastrointestinal tract and intestinal in situ formation of enFruAGEs, which once absorbed, travel beyond the intestinal boundaries to other tissues and promote inflammation. In separate studies, the accumulation of advanced glycation end-products has been associated with joint inflammation in RA. Objective of this study was to assess the association between EFF beverages intake and non-age, non-wear and tear-associated arthritis in US young adults. METHODS: In this cross sectional study of 1209 adults aged 20-30y, (Nutrition and Health Examination Surveys 2003-2006) exposure variables were high EFF beverages, including HFCS sweetened soft drinks, and any combination of HFCS sweetened soft drinks, fruit drinks (FD) and apple juice, referred to as tEFF. Analyses of diet soda and diet FD were included for comparison. The outcome was self-reported arthritis. Rao Scott Ҳ(2) was used for prevalence differences and logistic regression for associations, adjusted for confounders. RESULTS: Young adults consuming any combination of high EFF beverages (tEFF) ⩾5 times/week (but not diet soda) were three times as likely to have arthritis as non/low consumers (odds ratios=3.01; p⩽0.021; 95% confidence intervals=1.20-7.59), independent of all covariates, including physical activity, other dietary factors, blood glucose and smoking. CONCLUSION: EFF beverage intake is significantly associated with arthritis in US adults aged 20-30 years, possibly due to the intestinal in situ formation of enFruAGEs. SN - 2044-4052 UR - https://www.unboundmedicine.com/medline/citation/26950480/Intake_of_high_fructose_corn_syrup_sweetened_soft_drinks_fruit_drinks_and_apple_juice_is_associated_with_prevalent_arthritis_in_US_adults_aged_20_30_years_ L2 - http://dx.doi.org/10.1038/nutd.2016.7 DB - PRIME DP - Unbound Medicine ER -