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Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort.

Abstract

Although experimental studies suggest that fruits, vegetables and legumes may exert protective effects against prostate carcinogenesis through various bioactive compounds such as dietary fibre and antioxidants, epidemiological evidence is lacking. Notably, very few prospective studies have investigated the relationship between legume intake and prostate cancer risk. Our objective was to prospectively investigate the association between fruit, vegetable, tomato products, potatoes and legume intakes and prostate cancer risk. This study included 3313 male participants to the SUpplémentation en VItamines et Minéraux AntioXydants cohort (follow-up: 1994-2007) who completed at least three 24-h dietary records during the first 2 years of follow-up. Associations between tertiles of intake and prostate cancer risk were assessed by multivariate Cox proportional hazards models. After a median follow-up of 12·6 years, 139 incident prostate cancers were diagnosed. An inverse association was observed between prostate cancer risk and tertiles of legume intake (hazard ratio (HR)T3v.T1=0·53; 95 % CI 0·34, 0·85; P trend=0·009). This association was maintained after excluding soya and soya products from the legume group (HRT3 v.T1=0·56; 95 % CI 0·35, 0·89; P trend=0·02). No association was observed between prostate cancer risk and tertiles of intakes of fruits (P trend=0·25), vegetables (P trend=0·91), potatoes (P trend=0·77) and tomato products (P trend=0·09). This prospective study confirms the null association between fruit and non-starchy vegetable intakes and prostate cancer risk observed in most previous cohorts. In contrast, although very few prospective studies have been published on the topic, our results suggest an inverse association between legume intake and prostate cancer risk, supported by mechanistic plausibility. These results should be confirmed by large-scale observational and intervention studies.

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  • Authors+Show Affiliations

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    ,

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    1Sorbonne Paris Cité Epidemiology and Biostatistics Research Center,Inserm U1153,Inra U1125, Cnam,Paris 13, 5 and 7 Universities,Nutritional Epidemiology Research Team (EREN),13 avenue de Paris, 93000 Bobigny,France.

    Source

    The British journal of nutrition 115:9 2016 05 pg 1579-85

    MeSH

    Antioxidants
    Diet
    Diet Records
    Diet Surveys
    Fabaceae
    Feeding Behavior
    Fruit
    Humans
    Male
    Micronutrients
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26950824

    Citation

    Diallo, Abou, et al. "Associations Between Fruit, Vegetable and Legume Intakes and Prostate Cancer Risk: Results From the Prospective Supplémentation En Vitamines Et Minéraux Antioxydants (SU.VI.MAX) Cohort." The British Journal of Nutrition, vol. 115, no. 9, 2016, pp. 1579-85.
    Diallo A, Deschasaux M, Galan P, et al. Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort. Br J Nutr. 2016;115(9):1579-85.
    Diallo, A., Deschasaux, M., Galan, P., Hercberg, S., Zelek, L., Latino-Martel, P., & Touvier, M. (2016). Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort. The British Journal of Nutrition, 115(9), pp. 1579-85. doi:10.1017/S0007114516000520.
    Diallo A, et al. Associations Between Fruit, Vegetable and Legume Intakes and Prostate Cancer Risk: Results From the Prospective Supplémentation En Vitamines Et Minéraux Antioxydants (SU.VI.MAX) Cohort. Br J Nutr. 2016;115(9):1579-85. PubMed PMID: 26950824.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort. AU - Diallo,Abou, AU - Deschasaux,Mélanie, AU - Galan,Pilar, AU - Hercberg,Serge, AU - Zelek,Laurent, AU - Latino-Martel,Paule, AU - Touvier,Mathilde, Y1 - 2016/03/07/ PY - 2016/3/8/entrez PY - 2016/3/8/pubmed PY - 2017/5/6/medline KW - Fruits KW - HR hazard ratio KW - Legumes KW - PSA prostate-specific antigen KW - Prospective studies KW - Prostate cancer KW - SU.VI.MAX SUpplémentation en VItamines et Minéraux AntioXydants KW - Vegetables SP - 1579 EP - 85 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 9 N2 - Although experimental studies suggest that fruits, vegetables and legumes may exert protective effects against prostate carcinogenesis through various bioactive compounds such as dietary fibre and antioxidants, epidemiological evidence is lacking. Notably, very few prospective studies have investigated the relationship between legume intake and prostate cancer risk. Our objective was to prospectively investigate the association between fruit, vegetable, tomato products, potatoes and legume intakes and prostate cancer risk. This study included 3313 male participants to the SUpplémentation en VItamines et Minéraux AntioXydants cohort (follow-up: 1994-2007) who completed at least three 24-h dietary records during the first 2 years of follow-up. Associations between tertiles of intake and prostate cancer risk were assessed by multivariate Cox proportional hazards models. After a median follow-up of 12·6 years, 139 incident prostate cancers were diagnosed. An inverse association was observed between prostate cancer risk and tertiles of legume intake (hazard ratio (HR)T3v.T1=0·53; 95 % CI 0·34, 0·85; P trend=0·009). This association was maintained after excluding soya and soya products from the legume group (HRT3 v.T1=0·56; 95 % CI 0·35, 0·89; P trend=0·02). No association was observed between prostate cancer risk and tertiles of intakes of fruits (P trend=0·25), vegetables (P trend=0·91), potatoes (P trend=0·77) and tomato products (P trend=0·09). This prospective study confirms the null association between fruit and non-starchy vegetable intakes and prostate cancer risk observed in most previous cohorts. In contrast, although very few prospective studies have been published on the topic, our results suggest an inverse association between legume intake and prostate cancer risk, supported by mechanistic plausibility. These results should be confirmed by large-scale observational and intervention studies. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26950824/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114516000520/type/journal_article DB - PRIME DP - Unbound Medicine ER -