Tags

Type your tag names separated by a space and hit enter

[Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis].
Nippon Ganka Gakkai Zasshi 2016; 120(1):5-16NG

Abstract

PURPOSE

To investigate the current status of fungal keratitis in Japan.

METHODS

The patients with fungal keratitis were examined at 27 facilities in Japan from November 1st 2011 to October 31st 2013, concerning isolates, patient background, clinical findings, treatment and prognosis.

RESULTS

Out of 139 cases, 133 were diagnosed as fungal keratitis, of which fungi were isolated from 72 samples of 71 cases (yeast-like fungi 32 strains and filamentous fungi 40 strains). The corrected visual acuity at the first visit of 88 cases (66.2%) was less than 20/200 and 42 cases (31.6%) were involved with deep stromal lesions, indicating high proportion of severe cases in this study. Three months later, 56 cases (42.1%) were still under treatment, and corrected visual acuity of 57 cases (42.9%) was less than 20/200. In cases with yeast-like fungi, there were significantly more cases with past history of corneal diseases, ocular surgery including keratoplasty, and eye drops' use such as steroids than those with filamentous fungi. On the other hand, there were significantly more cases of filamentous fungi, with trauma on the onset and with intervention of previously attending doctors than those with yeast-like fungi. Logistic regression analyses revealed that contact lens wearing was a significant factor of good prognosis, and yeast-like fungi as one of poor outcome compared with no fungal isolation.

CONCLUSION

Although the choice of antifungal drugs has been increasing, fungal keratitis is still severe, refractory and vision-threatening disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Observational Study

Language

jpn

PubMed ID

26950964

Citation

Inoue, Yoshitsugu, et al. "[Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis]." Nippon Ganka Gakkai Zasshi, vol. 120, no. 1, 2016, pp. 5-16.
Inoue Y, Ohashi Y, Suzuki T, et al. [Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis]. Nippon Ganka Gakkai Zasshi. 2016;120(1):5-16.
Inoue, Y., Ohashi, Y., Suzuki, T., Shimomura, Y., Fukuda, M., Sotozono, C., ... Nejima, R. (2016). [Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis]. Nippon Ganka Gakkai Zasshi, 120(1), pp. 5-16.
Inoue Y, et al. [Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis]. Nippon Ganka Gakkai Zasshi. 2016;120(1):5-16. PubMed PMID: 26950964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Multicenter Prospective Observational Study of Fungal Keratitis--Current Status of Patients' Background, Clinical Findings, Treatment and Prognosis]. AU - Inoue,Yoshitsugu, AU - Ohashi,Yuichi, AU - Suzuki,Takashi, AU - Shimomura,Yoshikazu, AU - Fukuda,Masahiko, AU - Sotozono,Chie, AU - Hatano,Hiroshi, AU - Eguchi,Hiroshi, AU - Araki-Sasaki,Kaoru, AU - Hoshi,Saichi, AU - Sunada,Atsuko, AU - Asari,Seishi, AU - Yaguchi,Takashi, AU - Makimura,Koichi, AU - Yokokura,Shunji, AU - Mochizuki,Kiyofumi, AU - Monden,Yu, AU - Nejima,Ryohei, AU - ,, PY - 2016/3/9/entrez PY - 2016/3/10/pubmed PY - 2016/4/12/medline SP - 5 EP - 16 JF - Nippon Ganka Gakkai zasshi JO - Nippon Ganka Gakkai Zasshi VL - 120 IS - 1 N2 - PURPOSE: To investigate the current status of fungal keratitis in Japan. METHODS: The patients with fungal keratitis were examined at 27 facilities in Japan from November 1st 2011 to October 31st 2013, concerning isolates, patient background, clinical findings, treatment and prognosis. RESULTS: Out of 139 cases, 133 were diagnosed as fungal keratitis, of which fungi were isolated from 72 samples of 71 cases (yeast-like fungi 32 strains and filamentous fungi 40 strains). The corrected visual acuity at the first visit of 88 cases (66.2%) was less than 20/200 and 42 cases (31.6%) were involved with deep stromal lesions, indicating high proportion of severe cases in this study. Three months later, 56 cases (42.1%) were still under treatment, and corrected visual acuity of 57 cases (42.9%) was less than 20/200. In cases with yeast-like fungi, there were significantly more cases with past history of corneal diseases, ocular surgery including keratoplasty, and eye drops' use such as steroids than those with filamentous fungi. On the other hand, there were significantly more cases of filamentous fungi, with trauma on the onset and with intervention of previously attending doctors than those with yeast-like fungi. Logistic regression analyses revealed that contact lens wearing was a significant factor of good prognosis, and yeast-like fungi as one of poor outcome compared with no fungal isolation. CONCLUSION: Although the choice of antifungal drugs has been increasing, fungal keratitis is still severe, refractory and vision-threatening disease. SN - 0029-0203 UR - https://www.unboundmedicine.com/medline/citation/26950964/[Multicenter_Prospective_Observational_Study_of_Fungal_Keratitis__Current_Status_of_Patients'_Background_Clinical_Findings_Treatment_and_Prognosis]_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0029-0203&volume=120&issue=1&spage=5 DB - PRIME DP - Unbound Medicine ER -