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The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico.
Clin Rheumatol. 2016 Jun; 35(6):1457-62.CR

Abstract

Rheumatoid arthritis (RA) is a complex genetic disease. Human leukocyte antigen (HLA) and non-HLA genes are reportedly associated with an increased risk of RA. The protein tyrosine phosphatase non-receptor 22 gene (PTPN22), which encodes the lymphoid tyrosine phosphatase (LYP) protein, is one of the best examples of a non-HLA gene associated with a risk for RA in several populations. The functional PTPN22 C1858T (R620W) non-synonymous polymorphism is widely associated with an increased risk for RA in Europeans and non-Europeans. The aim of this study was to determine if the PTPN22 C1858T polymorphism confers susceptibility to RA in a sample of patients from Mexico. This study included 364 RA patients and 387 non-related controls from Central Mexico. Genotyping of the PTPN22 C1858T (rs2476601) polymorphism was performed using allelic discrimination assays with TaqMan probes. The functional PTPN22 C1858T polymorphism was associated with an increased risk for RA in our study population. The CC vs CT genotype in RA patients versus healthy controls had an odds ratio (OR) of 4.17 (95 % CI 1.79-9.74, p = 0.00036), while T allele had an OR of 4.06 (95 % CI 1.75-9.41, p = 0.00043). PTPN22 is a genetic risk factor for developing RA in the Mexican population.

Authors+Show Affiliations

Laboratorio de Oncología Molecular, Unidad de Diferenciación Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico.Laboratory of Genomic Medicine, Research Unit, Hospital Juárez de México, Av. Instituto Politécnico Nacional No. 5160, Delegación Gustavo A. Madero, C.P. 07760, Mexico City, Mexico. Licenciatura en QFBT, Universidad del Valle de México-Chapultepec, Mexico City, Mexico.Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.Servicio de Reumatología, Hospital Regional Lic. Adolfo López Mateos, Mexico City, Mexico.Servicio de Reumatología, Hospital Juárez de México, Mexico City, Mexico.Laboratory of Genomic Medicine, Research Unit, Hospital Juárez de México, Av. Instituto Politécnico Nacional No. 5160, Delegación Gustavo A. Madero, C.P. 07760, Mexico City, Mexico. dr.julian.ramirez.hjm@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26951256

Citation

Rincón, J F Mendoza, et al. "The Functional PTPN22 C1858T Polymorphism Confers Risk for Rheumatoid Arthritis in Patients From Central Mexico." Clinical Rheumatology, vol. 35, no. 6, 2016, pp. 1457-62.
Rincón JF, Cano DL, Morales SJ, et al. The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico. Clin Rheumatol. 2016;35(6):1457-62.
Rincón, J. F., Cano, D. L., Morales, S. J., Jiménez, M. L., Cobos, R. E., & Bello, J. R. (2016). The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico. Clinical Rheumatology, 35(6), 1457-62. https://doi.org/10.1007/s10067-016-3223-z
Rincón JF, et al. The Functional PTPN22 C1858T Polymorphism Confers Risk for Rheumatoid Arthritis in Patients From Central Mexico. Clin Rheumatol. 2016;35(6):1457-62. PubMed PMID: 26951256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico. AU - Rincón,J F Mendoza, AU - Cano,D López, AU - Morales,S Jiménez, AU - Jiménez,M L Rivas, AU - Cobos,R E Barbosa, AU - Bello,J Ramírez, Y1 - 2016/03/07/ PY - 2015/12/23/received PY - 2016/02/21/accepted PY - 2016/02/10/revised PY - 2016/3/9/entrez PY - 2016/3/10/pubmed PY - 2017/3/16/medline KW - PTPN22 KW - Rheumatoid arthritis KW - Single nucleotide polymorphism KW - Susceptibility SP - 1457 EP - 62 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 35 IS - 6 N2 - Rheumatoid arthritis (RA) is a complex genetic disease. Human leukocyte antigen (HLA) and non-HLA genes are reportedly associated with an increased risk of RA. The protein tyrosine phosphatase non-receptor 22 gene (PTPN22), which encodes the lymphoid tyrosine phosphatase (LYP) protein, is one of the best examples of a non-HLA gene associated with a risk for RA in several populations. The functional PTPN22 C1858T (R620W) non-synonymous polymorphism is widely associated with an increased risk for RA in Europeans and non-Europeans. The aim of this study was to determine if the PTPN22 C1858T polymorphism confers susceptibility to RA in a sample of patients from Mexico. This study included 364 RA patients and 387 non-related controls from Central Mexico. Genotyping of the PTPN22 C1858T (rs2476601) polymorphism was performed using allelic discrimination assays with TaqMan probes. The functional PTPN22 C1858T polymorphism was associated with an increased risk for RA in our study population. The CC vs CT genotype in RA patients versus healthy controls had an odds ratio (OR) of 4.17 (95 % CI 1.79-9.74, p = 0.00036), while T allele had an OR of 4.06 (95 % CI 1.75-9.41, p = 0.00043). PTPN22 is a genetic risk factor for developing RA in the Mexican population. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/26951256/The_functional_PTPN22_C1858T_polymorphism_confers_risk_for_rheumatoid_arthritis_in_patients_from_Central_Mexico_ L2 - https://dx.doi.org/10.1007/s10067-016-3223-z DB - PRIME DP - Unbound Medicine ER -