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Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.
Neurotox Res. 2016 07; 30(1):41-52.NR

Abstract

Neurodegenerative disorders have a common characteristic that is the involvement of different cell types, typically the reactivity of astrocytes and microglia, characterizing gliosis, which in turn contributes to the neuronal dysfunction and or death. Flavonoids are secondary metabolites of plant origin widely investigated at present and represent one of the most important and diversified among natural products phenolic groups. Several biological activities are attributed to this class of polyphenols, such as antitumor activity, antioxidant, antiviral, and anti-inflammatory, among others, which give significant pharmacological importance. Our group have observed that flavonoids derived from Brazilian plants Dimorphandra mollis Bent., Croton betulaster Müll. Arg., e Poincianella pyramidalis Tul., botanical synonymous Caesalpinia pyramidalis Tul. also elicit a broad spectrum of responses in astrocytes and neurons in culture as activation of astrocytes and microglia, astrocyte associated protection of neuronal progenitor cells, neuronal differentiation and neuritogenesis. It was observed the flavonoids also induced neuronal differentiation of mouse embryonic stem cells and human pluripotent stem cells. Moreover, with the objective of seeking preclinical pharmacological evidence of these molecules, in order to assess its future use in the treatment of neurodegenerative disorders, we have evaluated the effects of flavonoids in preclinical in vitro models of neuroinflammation associated with Parkinson's disease and glutamate toxicity associated with ischemia. In particular, our efforts have been directed to identify mechanisms involved in the changes in viability, morphology, and glial cell function induced by flavonoids in cultures of glial cells and neuronal cells alone or in interactions and clarify the relation with their neuroprotective and morphogetic effects.

Authors+Show Affiliations

Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. costasl2011@gmail.com.Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil.Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil.Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil.Department of Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chile. Depertamento de Ciencias Basicas, Universidad Santo Tomas, Viña del Mar, Chile.Department of Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chile.Department of Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chile.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26951456

Citation

Costa, Silvia Lima, et al. "Impact of Plant-Derived Flavonoids On Neurodegenerative Diseases." Neurotoxicity Research, vol. 30, no. 1, 2016, pp. 41-52.
Costa SL, Silva VD, Dos Santos Souza C, et al. Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases. Neurotox Res. 2016;30(1):41-52.
Costa, S. L., Silva, V. D., Dos Santos Souza, C., Santos, C. C., Paris, I., Muñoz, P., & Segura-Aguilar, J. (2016). Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases. Neurotoxicity Research, 30(1), 41-52. https://doi.org/10.1007/s12640-016-9600-1
Costa SL, et al. Impact of Plant-Derived Flavonoids On Neurodegenerative Diseases. Neurotox Res. 2016;30(1):41-52. PubMed PMID: 26951456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases. AU - Costa,Silvia Lima, AU - Silva,Victor Diogenes Amaral, AU - Dos Santos Souza,Cleide, AU - Santos,Cleonice Creusa, AU - Paris,Irmgard, AU - Muñoz,Patricia, AU - Segura-Aguilar,Juan, Y1 - 2016/03/07/ PY - 2015/10/01/received PY - 2016/01/21/accepted PY - 2015/12/24/revised PY - 2016/3/9/entrez PY - 2016/3/10/pubmed PY - 2017/6/27/medline KW - Astrocytes KW - Flavonoids KW - Microglia KW - Neuroprotection KW - Neuroritogenesis SP - 41 EP - 52 JF - Neurotoxicity research JO - Neurotox Res VL - 30 IS - 1 N2 - Neurodegenerative disorders have a common characteristic that is the involvement of different cell types, typically the reactivity of astrocytes and microglia, characterizing gliosis, which in turn contributes to the neuronal dysfunction and or death. Flavonoids are secondary metabolites of plant origin widely investigated at present and represent one of the most important and diversified among natural products phenolic groups. Several biological activities are attributed to this class of polyphenols, such as antitumor activity, antioxidant, antiviral, and anti-inflammatory, among others, which give significant pharmacological importance. Our group have observed that flavonoids derived from Brazilian plants Dimorphandra mollis Bent., Croton betulaster Müll. Arg., e Poincianella pyramidalis Tul., botanical synonymous Caesalpinia pyramidalis Tul. also elicit a broad spectrum of responses in astrocytes and neurons in culture as activation of astrocytes and microglia, astrocyte associated protection of neuronal progenitor cells, neuronal differentiation and neuritogenesis. It was observed the flavonoids also induced neuronal differentiation of mouse embryonic stem cells and human pluripotent stem cells. Moreover, with the objective of seeking preclinical pharmacological evidence of these molecules, in order to assess its future use in the treatment of neurodegenerative disorders, we have evaluated the effects of flavonoids in preclinical in vitro models of neuroinflammation associated with Parkinson's disease and glutamate toxicity associated with ischemia. In particular, our efforts have been directed to identify mechanisms involved in the changes in viability, morphology, and glial cell function induced by flavonoids in cultures of glial cells and neuronal cells alone or in interactions and clarify the relation with their neuroprotective and morphogetic effects. SN - 1476-3524 UR - https://www.unboundmedicine.com/medline/citation/26951456/Impact_of_Plant_Derived_Flavonoids_on_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -