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Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome.
Gynecol Endocrinol. 2016 Sep; 32(9):709-713.GE

Abstract

This prospective study aimed to determine the status of circulating levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), IL-27, IL-35, IL-37, α-1 acid glycoprotein in patients with polycystic ovary syndrome (PCOS) compared with controls and to evaluate their relation with hyperandrogenism and obesity. Forty-eight patients with PCOS (29 obese, 19 lean) and 40 healthy controls (20 obese, 20 lean) were enrolled. CRP, TNF-α, IL-27, IL-35, IL-37, α-1 acid glycoprotein, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S) levels were measured. Levels of total testosterone, A4, DHEA-S were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while levels of SHBG were significantly lower in all patients with PCOS than in all (p < 0.05). Free androgen index (FAI) values were significantly higher in all patients with PCOS than in all controls (all p < 0.05). Levels of CRP, TNF-α, α-1 acid glycoprotein were significantly increased in all patients with PCOS compared with all controls (all p < 0.001). FAI had a positive correlation with CRP, TNF-α, α-1 acid glycoprotein, a negative correlation with IL-27, IL-25, IL-37 (all p < 0.01). Body mass index had a negative correlation with IL-27, IL-35, IL-37, a positive correlation with α-1 acid glycoprotein, FAI (p < 0.05). The findings confirm the proinflammatory state of PCOS. Moreover, obesity along with PCOS significantly elevates the inflammatory status and hyperandrogenism.

Authors+Show Affiliations

a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.b Department of Biochemistry , Bezmialem Foundation University, Faculty of Science , Istanbul , Turkey.a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26951881

Citation

Nehir Aytan, Asli, et al. "Relationship Between Hyperandrogenism, Obesity, Inflammation and Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 32, no. 9, 2016, pp. 709-713.
Nehir Aytan A, Bastu E, Demiral I, et al. Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome. Gynecol Endocrinol. 2016;32(9):709-713.
Nehir Aytan, A., Bastu, E., Demiral, I., Bulut, H., Dogan, M., & Buyru, F. (2016). Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 32(9), 709-713.
Nehir Aytan A, et al. Relationship Between Hyperandrogenism, Obesity, Inflammation and Polycystic Ovary Syndrome. Gynecol Endocrinol. 2016;32(9):709-713. PubMed PMID: 26951881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome. AU - Nehir Aytan,Asli, AU - Bastu,Ercan, AU - Demiral,Irem, AU - Bulut,Huri, AU - Dogan,Murat, AU - Buyru,Faruk, Y1 - 2016/03/07/ PY - 2016/3/10/pubmed PY - 2017/5/11/medline PY - 2016/3/9/entrez KW - Hyperandrogenism KW - inflammation KW - obesity KW - polycystic ovary syndrome SP - 709 EP - 713 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 32 IS - 9 N2 - This prospective study aimed to determine the status of circulating levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), IL-27, IL-35, IL-37, α-1 acid glycoprotein in patients with polycystic ovary syndrome (PCOS) compared with controls and to evaluate their relation with hyperandrogenism and obesity. Forty-eight patients with PCOS (29 obese, 19 lean) and 40 healthy controls (20 obese, 20 lean) were enrolled. CRP, TNF-α, IL-27, IL-35, IL-37, α-1 acid glycoprotein, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S) levels were measured. Levels of total testosterone, A4, DHEA-S were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while levels of SHBG were significantly lower in all patients with PCOS than in all (p < 0.05). Free androgen index (FAI) values were significantly higher in all patients with PCOS than in all controls (all p < 0.05). Levels of CRP, TNF-α, α-1 acid glycoprotein were significantly increased in all patients with PCOS compared with all controls (all p < 0.001). FAI had a positive correlation with CRP, TNF-α, α-1 acid glycoprotein, a negative correlation with IL-27, IL-25, IL-37 (all p < 0.01). Body mass index had a negative correlation with IL-27, IL-35, IL-37, a positive correlation with α-1 acid glycoprotein, FAI (p < 0.05). The findings confirm the proinflammatory state of PCOS. Moreover, obesity along with PCOS significantly elevates the inflammatory status and hyperandrogenism. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/26951881/Relationship_between_hyperandrogenism_obesity_inflammation_and_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2016.1155208 DB - PRIME DP - Unbound Medicine ER -