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Carbohydrate, lipid and amino acid metabolism of insulin-dependent diabetic patients regulated by an artificial beta-cell unit.
Diabetes Res. 1989 May; 11(1):1-8.DR

Abstract

To characterize the effects of artificial beta-cell directed insulin therapy on carbohydrate, lipid and amino acid metabolism, five insulin-dependent diabetic patients were challenged with a 100-g glucose meal while on conventional (single or split mixed insulin injections) therapy and again after 72 hr on an artificial beta-cell unit. It was verified that the high levels of blood glucose of the conventionally treated diabetics were marked reduced toward normal by the artificial beta-cell therapy, while the blood lactate and pyruvate concentrations increased significantly to levels higher than in normal controls. The elevated levels of FFA, glycerol, and ketones in the diabetics under conventional therapy were entirely normalized during the artificial beta-cell regulation. Furthermore, the artificial beta-cell insulin therapy showed capable to restore the abnormalities in the blood profiles of alanine, glutamine and branched-chain amino acids, exceeding in some points the normal response. It was also detected hyperinsulinemia in the diabetics treated with the artificial beta-cell unit and no change in the pancreatic beta-cell function during this period of regulation, evidenced by low and unchanged blood levels of C-peptide. Marked suppression of pancreatic alpha-cell secretion was detected by the significant decrease of the hyperglucagonemia in the conventionally treated diabetics by the artificial beta-cell therapy. These studies reveal that the artificial beta-cell insulin therapy is capable of restoring to normal not only the abnormal glucose metabolism of conventionally treated diabetics, but also other substrate metabolism related to the lipid and protein homeostasis of the organism.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

E.P. Joslin Research Laboratory--Joslin Diabetes Center, Harvard Medical School, Boston.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2695278

Citation

Foss, M C., et al. "Carbohydrate, Lipid and Amino Acid Metabolism of Insulin-dependent Diabetic Patients Regulated By an Artificial Beta-cell Unit." Diabetes Research (Edinburgh, Scotland), vol. 11, no. 1, 1989, pp. 1-8.
Foss MC, Vlachokosta FV, Aoki TT. Carbohydrate, lipid and amino acid metabolism of insulin-dependent diabetic patients regulated by an artificial beta-cell unit. Diabetes Res. 1989;11(1):1-8.
Foss, M. C., Vlachokosta, F. V., & Aoki, T. T. (1989). Carbohydrate, lipid and amino acid metabolism of insulin-dependent diabetic patients regulated by an artificial beta-cell unit. Diabetes Research (Edinburgh, Scotland), 11(1), 1-8.
Foss MC, Vlachokosta FV, Aoki TT. Carbohydrate, Lipid and Amino Acid Metabolism of Insulin-dependent Diabetic Patients Regulated By an Artificial Beta-cell Unit. Diabetes Res. 1989;11(1):1-8. PubMed PMID: 2695278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate, lipid and amino acid metabolism of insulin-dependent diabetic patients regulated by an artificial beta-cell unit. AU - Foss,M C, AU - Vlachokosta,F V, AU - Aoki,T T, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 1 EP - 8 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res VL - 11 IS - 1 N2 - To characterize the effects of artificial beta-cell directed insulin therapy on carbohydrate, lipid and amino acid metabolism, five insulin-dependent diabetic patients were challenged with a 100-g glucose meal while on conventional (single or split mixed insulin injections) therapy and again after 72 hr on an artificial beta-cell unit. It was verified that the high levels of blood glucose of the conventionally treated diabetics were marked reduced toward normal by the artificial beta-cell therapy, while the blood lactate and pyruvate concentrations increased significantly to levels higher than in normal controls. The elevated levels of FFA, glycerol, and ketones in the diabetics under conventional therapy were entirely normalized during the artificial beta-cell regulation. Furthermore, the artificial beta-cell insulin therapy showed capable to restore the abnormalities in the blood profiles of alanine, glutamine and branched-chain amino acids, exceeding in some points the normal response. It was also detected hyperinsulinemia in the diabetics treated with the artificial beta-cell unit and no change in the pancreatic beta-cell function during this period of regulation, evidenced by low and unchanged blood levels of C-peptide. Marked suppression of pancreatic alpha-cell secretion was detected by the significant decrease of the hyperglucagonemia in the conventionally treated diabetics by the artificial beta-cell therapy. These studies reveal that the artificial beta-cell insulin therapy is capable of restoring to normal not only the abnormal glucose metabolism of conventionally treated diabetics, but also other substrate metabolism related to the lipid and protein homeostasis of the organism.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2695278/Carbohydrate_lipid_and_amino_acid_metabolism_of_insulin_dependent_diabetic_patients_regulated_by_an_artificial_beta_cell_unit_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -