Tags

Type your tag names separated by a space and hit enter

Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1.
World J Surg. 2016 Jul; 40(7):1729-36.WJ

Abstract

OBJECTIVE

The role of minimally invasive pancreatic surgery for pancreatic neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1) is not well defined. The aim of this study was to compare the outcome of minimally invasive versus open pancreatic resections in patients with MEN1.

MATERIALS AND METHODS

Prospectively collected data of MEN1 patients who underwent a primary distal pancreatic resection and/or enucleation for non-functioning pNENs or insulinoma were retrospectively analyzed regarding the outcome of minimally invasive or open pancreatic resections.

RESULTS

Thirty-three patients underwent primary pancreatic resection for either organic hyperinsulinism (n = 9, 27 %) or non-functioning pNENs >1 cm in size (n = 24, 73 %) between 1987 and 2015. 21 (64 %) patients underwent an open surgical (group 1) and 12 patients (36 %) a minimally invasive approach, either laparoscopic (n = 8) or robotic assisted (n = 4) (group 2). Both groups were comparable regarding age, gender, number, and size of pancreatic tumors. In both groups, the hyperinsulinism of all patients (9/9,100 %) could be cured and all NF-pNENs >1 cm could be resected. Group 2 had a significant shorter operative time (200 vs. 260 min; p = 0.036), less intraoperative blood loss (120 vs. 280 ml; p < 0.001), and a shorter hospital stay (11 vs. 15.5 days; p = 0.034). The rate of patients with postoperative complications, especially postoperative pancreatic fistulas, was not different between groups (62 % group 1 vs. 67 % group 2, p = 0.74).

CONCLUSION

Minimally invasive distal pancreatic resections and enucleations are feasible and safe in MEN1 patients with insulinoma or non-functioning pNENs.

Authors+Show Affiliations

Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany. lopez@med.uni-marburg.de.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26956903

Citation

Lopez, Caroline L., et al. "Minimally Invasive Versus Open Pancreatic Surgery in Patients With Multiple Endocrine Neoplasia Type 1." World Journal of Surgery, vol. 40, no. 7, 2016, pp. 1729-36.
Lopez CL, Albers MB, Bollmann C, et al. Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1. World J Surg. 2016;40(7):1729-36.
Lopez, C. L., Albers, M. B., Bollmann, C., Manoharan, J., Waldmann, J., Fendrich, V., & Bartsch, D. K. (2016). Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1. World Journal of Surgery, 40(7), 1729-36. https://doi.org/10.1007/s00268-016-3456-7
Lopez CL, et al. Minimally Invasive Versus Open Pancreatic Surgery in Patients With Multiple Endocrine Neoplasia Type 1. World J Surg. 2016;40(7):1729-36. PubMed PMID: 26956903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1. AU - Lopez,Caroline L, AU - Albers,Max B, AU - Bollmann,Carmen, AU - Manoharan,Jerena, AU - Waldmann,Jens, AU - Fendrich,Volker, AU - Bartsch,Detlef K, PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2017/2/15/medline SP - 1729 EP - 36 JF - World journal of surgery JO - World J Surg VL - 40 IS - 7 N2 - OBJECTIVE: The role of minimally invasive pancreatic surgery for pancreatic neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1) is not well defined. The aim of this study was to compare the outcome of minimally invasive versus open pancreatic resections in patients with MEN1. MATERIALS AND METHODS: Prospectively collected data of MEN1 patients who underwent a primary distal pancreatic resection and/or enucleation for non-functioning pNENs or insulinoma were retrospectively analyzed regarding the outcome of minimally invasive or open pancreatic resections. RESULTS: Thirty-three patients underwent primary pancreatic resection for either organic hyperinsulinism (n = 9, 27 %) or non-functioning pNENs >1 cm in size (n = 24, 73 %) between 1987 and 2015. 21 (64 %) patients underwent an open surgical (group 1) and 12 patients (36 %) a minimally invasive approach, either laparoscopic (n = 8) or robotic assisted (n = 4) (group 2). Both groups were comparable regarding age, gender, number, and size of pancreatic tumors. In both groups, the hyperinsulinism of all patients (9/9,100 %) could be cured and all NF-pNENs >1 cm could be resected. Group 2 had a significant shorter operative time (200 vs. 260 min; p = 0.036), less intraoperative blood loss (120 vs. 280 ml; p < 0.001), and a shorter hospital stay (11 vs. 15.5 days; p = 0.034). The rate of patients with postoperative complications, especially postoperative pancreatic fistulas, was not different between groups (62 % group 1 vs. 67 % group 2, p = 0.74). CONCLUSION: Minimally invasive distal pancreatic resections and enucleations are feasible and safe in MEN1 patients with insulinoma or non-functioning pNENs. SN - 1432-2323 UR - https://www.unboundmedicine.com/medline/citation/26956903/Minimally_Invasive_Versus_Open_Pancreatic_Surgery_in_Patients_with_Multiple_Endocrine_Neoplasia_Type_1_ L2 - https://dx.doi.org/10.1007/s00268-016-3456-7 DB - PRIME DP - Unbound Medicine ER -