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Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats.
Pharm Biol. 2016 Oct; 54(10):2092-102.PB

Abstract

Context Sumac [Rhus coriaria L. (RC) (Anacardiaceae)] is used as a folk medicine in the treatment of diabetes in Turkey. Objective This study investigates the in vivo healing and protective effects of lyophilized extract sumac against streptozotocin (STZ)-induced diabetic complications. Materials and methods Toxicity test was conducted in three different dosages (250, 500 and 1000 mg/kg of plant extracts, respectively). Six groups of seven rats each were used in experiments. Groups were designed as Normal control, Diabetic (DM), DM + AC-20 mg/kg, DM + Extract-100 mg/kg, DM + Extract 250 mg/kg and DM + Extract 500 mg/kg group. Experimental diabetes [50 mg/kg, intraperitoneal (i.p.)] was induced by STZ. The effects of oral administration of the extract for 21 d on the level of serum glucose, insulin, C-peptide, lipid profile (LP), hepatic and renal damage biomarkers (HRDB), diabetic serum biomarkers (DSB), glycosylated haemoglobin (HbA1c), antioxidant defence system constituents (ADSCs), malondialdehyde (MDA) and α-glucosidase activity in small intestine tissue were evaluated. Results The extract decreased the levels of blood glucose in diabetic groups (an average of 31%). Triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were balanced by plant extract (500 mg/kg) supplementation in the diabetic group. Decreased levels of aspartate aminotransferase (89%), alanine aminotransferase (91%), lactate dehydrogenase (35%), alkaline phosphatase (47%), creatinine (25%) and urea (29%) were detected in plant extract (500 mg/kg) supplemented diabetic group. Additionally, a considerable increase in the HRDB, DSB, LP, MDA and fluctuated ADSC levels were restored in RC-extract supplemented groups. Conclusion RC lyophilized extract has a healing effect on diabetes and diabetes-related complications.

Authors+Show Affiliations

a Faculty of Science, Department of Biology , Yuzuncu Yil University , Van , Turkey ;b Faculty of Science, Department of Molecular Biology and Genetics , Yuzuncu Yil University , Van , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26957014

Citation

Doğan, Abdulahad, and İsmail Çelik. "Healing Effects of Sumac (Rhus Coriaria) in Streptozotocin-induced Diabetic Rats." Pharmaceutical Biology, vol. 54, no. 10, 2016, pp. 2092-102.
Doğan A, Çelik İ. Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats. Pharm Biol. 2016;54(10):2092-102.
Doğan, A., & Çelik, İ. (2016). Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 54(10), 2092-102. https://doi.org/10.3109/13880209.2016.1145702
Doğan A, Çelik İ. Healing Effects of Sumac (Rhus Coriaria) in Streptozotocin-induced Diabetic Rats. Pharm Biol. 2016;54(10):2092-102. PubMed PMID: 26957014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats. AU - Doğan,Abdulahad, AU - Çelik,İsmail, Y1 - 2016/03/09/ PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2017/2/9/medline KW - antidiabetic KW - antioxidant KW - hepatoprotective KW - α-Glucosidase SP - 2092 EP - 102 JF - Pharmaceutical biology JO - Pharm Biol VL - 54 IS - 10 N2 - Context Sumac [Rhus coriaria L. (RC) (Anacardiaceae)] is used as a folk medicine in the treatment of diabetes in Turkey. Objective This study investigates the in vivo healing and protective effects of lyophilized extract sumac against streptozotocin (STZ)-induced diabetic complications. Materials and methods Toxicity test was conducted in three different dosages (250, 500 and 1000 mg/kg of plant extracts, respectively). Six groups of seven rats each were used in experiments. Groups were designed as Normal control, Diabetic (DM), DM + AC-20 mg/kg, DM + Extract-100 mg/kg, DM + Extract 250 mg/kg and DM + Extract 500 mg/kg group. Experimental diabetes [50 mg/kg, intraperitoneal (i.p.)] was induced by STZ. The effects of oral administration of the extract for 21 d on the level of serum glucose, insulin, C-peptide, lipid profile (LP), hepatic and renal damage biomarkers (HRDB), diabetic serum biomarkers (DSB), glycosylated haemoglobin (HbA1c), antioxidant defence system constituents (ADSCs), malondialdehyde (MDA) and α-glucosidase activity in small intestine tissue were evaluated. Results The extract decreased the levels of blood glucose in diabetic groups (an average of 31%). Triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were balanced by plant extract (500 mg/kg) supplementation in the diabetic group. Decreased levels of aspartate aminotransferase (89%), alanine aminotransferase (91%), lactate dehydrogenase (35%), alkaline phosphatase (47%), creatinine (25%) and urea (29%) were detected in plant extract (500 mg/kg) supplemented diabetic group. Additionally, a considerable increase in the HRDB, DSB, LP, MDA and fluctuated ADSC levels were restored in RC-extract supplemented groups. Conclusion RC lyophilized extract has a healing effect on diabetes and diabetes-related complications. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/26957014/Healing_effects_of_sumac__Rhus_coriaria__in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2016.1145702 DB - PRIME DP - Unbound Medicine ER -