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Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives.
Annu Rev Virol. 2015 Nov; 2(1):95-117.AR

Abstract

Coronaviruses have frequently expanded their host range in recent history, with two events resulting in severe disease outbreaks in human populations. Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2003 in Southeast Asia and rapidly spread around the world before it was controlled by public health intervention strategies. The 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak represents another prime example of virus emergence from a zoonotic reservoir. Here, we review the current knowledge of coronavirus cross-species transmission, with particular focus on MERS-CoV. MERS-CoV is still circulating in the human population, and the mechanisms governing its cross-species transmission have been only partially elucidated, highlighting a need for further investigation. We discuss biochemical determinants mediating MERS-CoV host cell permissivity, including virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and evolutionary mechanisms that may facilitate host range expansion, including recombination, mutator alleles, and mutational robustness. Understanding these mechanisms can help us better recognize the threat of emergence for currently circulating zoonotic strains.

Authors+Show Affiliations

Departments of 1Biology.Departments of 1Biology.Genetics. Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599; email: rbaric@email.unc.edu.Epidemiology, and. Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599; email: rbaric@email.unc.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

26958908

Citation

Peck, Kayla M., et al. "Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives." Annual Review of Virology, vol. 2, no. 1, 2015, pp. 95-117.
Peck KM, Burch CL, Heise MT, et al. Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives. Annu Rev Virol. 2015;2(1):95-117.
Peck, K. M., Burch, C. L., Heise, M. T., & Baric, R. S. (2015). Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives. Annual Review of Virology, 2(1), 95-117. https://doi.org/10.1146/annurev-virology-100114-055029
Peck KM, et al. Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives. Annu Rev Virol. 2015;2(1):95-117. PubMed PMID: 26958908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives. AU - Peck,Kayla M, AU - Burch,Christina L, AU - Heise,Mark T, AU - Baric,Ralph S, Y1 - 2015/08/07/ PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2016/10/27/medline KW - emergence KW - host cell receptor KW - mutational robustness KW - mutator alleles KW - recombination KW - virus evolution SP - 95 EP - 117 JF - Annual review of virology JO - Annu Rev Virol VL - 2 IS - 1 N2 - Coronaviruses have frequently expanded their host range in recent history, with two events resulting in severe disease outbreaks in human populations. Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2003 in Southeast Asia and rapidly spread around the world before it was controlled by public health intervention strategies. The 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak represents another prime example of virus emergence from a zoonotic reservoir. Here, we review the current knowledge of coronavirus cross-species transmission, with particular focus on MERS-CoV. MERS-CoV is still circulating in the human population, and the mechanisms governing its cross-species transmission have been only partially elucidated, highlighting a need for further investigation. We discuss biochemical determinants mediating MERS-CoV host cell permissivity, including virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and evolutionary mechanisms that may facilitate host range expansion, including recombination, mutator alleles, and mutational robustness. Understanding these mechanisms can help us better recognize the threat of emergence for currently circulating zoonotic strains. SN - 2327-0578 UR - https://www.unboundmedicine.com/medline/citation/26958908/Coronavirus_Host_Range_Expansion_and_Middle_East_Respiratory_Syndrome_Coronavirus_Emergence:_Biochemical_Mechanisms_and_Evolutionary_Perspectives_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev-virology-100114-055029?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -