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Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease.

Abstract

Circulating vitamin D has previously been found to be lower in patients with Parkinson's disease (PD), while the effects of sunlight exposure have not yet been fully investigated. Therefore, we evaluated the associations between serum vitamin D, vitamin D intake, sunlight exposure, and newly-diagnosed PD patients in a Chinese population. This case-control study measured serum 25-hydroxyvitamin D (25(OH)D) levels and sunlight exposure in 201 patients with newly-diagnosed PD and 199 controls without neurodegenerative diseases. Data on vitamin D intake and sunlight exposure were obtained using a self-report questionnaire. Multivariable logistic regressions were employed to evaluate the associations between serum 25(OH)D levels, sunlight exposure, and PD. Adjustments were made for sex, age, smoking, alcohol use, education, BMI, and vitamin D intake. There were significantly lower levels of serum 25(OH)D (20.6 ± 6.5 ng/mL), daily vitamin D intake (8.3 ± 3.7 g/day), and sunlight exposure (9.7 ± 4.1 h/week) in patients with PD compared to healthy controls (p < 0.05). Crude odds ratios (ORs) for PD in the quartiles of serum 25(OH)D were 1 (reference), 0.710 (0.401, 1.257), 0.631 (0.348, 1.209), and 0.483 (0.267, 0.874), respectively. Crude ORs for PD in quartiles of sunlight exposure were 1 (reference), 0.809 (0.454, 1.443), 0.623 (0.345, 1.124) and 0.533 (0.294, 0.966), respectively. A significant positive correlation between serum 25(OH)D and sunlight exposure was found, but serum 25(OH)D was not correlated with daily vitamin D intake. This study indicates that lower levels of serum 25(OH)D and sunlight exposure are significantly associated with an increased risk for PD.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China. wxsyzc@yeah.net.

    ,

    Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China. wakeupinfall@126.com.

    ,

    Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China. yuyu_1007@yeah.net.

    ,

    Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China. shaogaohai567@163.com.

    Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China. wqb631113@163.com.

    Source

    Nutrients 8:3 2016 Mar 04 pg 142

    MeSH

    Aged
    Biomarkers
    Case-Control Studies
    Chi-Square Distribution
    China
    Female
    Humans
    Linear Models
    Logistic Models
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Parkinson Disease
    Risk Factors
    Sunlight
    Surveys and Questionnaires
    Time Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26959053

    Citation

    Wang, Juan, et al. "Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease." Nutrients, vol. 8, no. 3, 2016, p. 142.
    Wang J, Yang D, Yu Y, et al. Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease. Nutrients. 2016;8(3):142.
    Wang, J., Yang, D., Yu, Y., Shao, G., & Wang, Q. (2016). Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease. Nutrients, 8(3), p. 142. doi:10.3390/nu8030142.
    Wang J, et al. Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease. Nutrients. 2016 Mar 4;8(3):142. PubMed PMID: 26959053.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D and Sunlight Exposure in Newly-Diagnosed Parkinson's Disease. AU - Wang,Juan, AU - Yang,Deyu, AU - Yu,Yu, AU - Shao,Gaohai, AU - Wang,Qunbo, Y1 - 2016/03/04/ PY - 2015/11/24/received PY - 2016/02/15/revised PY - 2016/02/24/accepted PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2016/12/15/medline KW - Parkinson’s disease KW - sunlight exposure KW - vitamin D SP - 142 EP - 142 JF - Nutrients JO - Nutrients VL - 8 IS - 3 N2 - Circulating vitamin D has previously been found to be lower in patients with Parkinson's disease (PD), while the effects of sunlight exposure have not yet been fully investigated. Therefore, we evaluated the associations between serum vitamin D, vitamin D intake, sunlight exposure, and newly-diagnosed PD patients in a Chinese population. This case-control study measured serum 25-hydroxyvitamin D (25(OH)D) levels and sunlight exposure in 201 patients with newly-diagnosed PD and 199 controls without neurodegenerative diseases. Data on vitamin D intake and sunlight exposure were obtained using a self-report questionnaire. Multivariable logistic regressions were employed to evaluate the associations between serum 25(OH)D levels, sunlight exposure, and PD. Adjustments were made for sex, age, smoking, alcohol use, education, BMI, and vitamin D intake. There were significantly lower levels of serum 25(OH)D (20.6 ± 6.5 ng/mL), daily vitamin D intake (8.3 ± 3.7 g/day), and sunlight exposure (9.7 ± 4.1 h/week) in patients with PD compared to healthy controls (p < 0.05). Crude odds ratios (ORs) for PD in the quartiles of serum 25(OH)D were 1 (reference), 0.710 (0.401, 1.257), 0.631 (0.348, 1.209), and 0.483 (0.267, 0.874), respectively. Crude ORs for PD in quartiles of sunlight exposure were 1 (reference), 0.809 (0.454, 1.443), 0.623 (0.345, 1.124) and 0.533 (0.294, 0.966), respectively. A significant positive correlation between serum 25(OH)D and sunlight exposure was found, but serum 25(OH)D was not correlated with daily vitamin D intake. This study indicates that lower levels of serum 25(OH)D and sunlight exposure are significantly associated with an increased risk for PD. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26959053/Vitamin_D_and_Sunlight_Exposure_in_Newly_Diagnosed_Parkinson's_Disease_ L2 - http://www.mdpi.com/resolver?pii=nu8030142 DB - PRIME DP - Unbound Medicine ER -