Tags

Type your tag names separated by a space and hit enter

Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method.
Acta Pharm. 2016 Mar; 66(1):119-28.AP

Abstract

The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26959548

Citation

Karolewicz, Bożena, et al. "Physicochemical Characterization and Dissolution Studies of Acyclovir Solid Dispersions With Pluronic F127 Prepared By the Kneading Method." Acta Pharmaceutica (Zagreb, Croatia), vol. 66, no. 1, 2016, pp. 119-28.
Karolewicz B, Nartowski K, Pluta J, et al. Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method. Acta Pharm. 2016;66(1):119-28.
Karolewicz, B., Nartowski, K., Pluta, J., & Górniak, A. (2016). Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method. Acta Pharmaceutica (Zagreb, Croatia), 66(1), 119-28. https://doi.org/10.1515/acph-2016-0008
Karolewicz B, et al. Physicochemical Characterization and Dissolution Studies of Acyclovir Solid Dispersions With Pluronic F127 Prepared By the Kneading Method. Acta Pharm. 2016;66(1):119-28. PubMed PMID: 26959548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method. AU - Karolewicz,Bożena, AU - Nartowski,Karol, AU - Pluta,Janusz, AU - Górniak,Agata, PY - 2015/09/28/accepted PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2016/12/15/medline SP - 119 EP - 28 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 66 IS - 1 N2 - The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %. SN - 1846-9558 UR - https://www.unboundmedicine.com/medline/citation/26959548/Physicochemical_characterization_and_dissolution_studies_of_acyclovir_solid_dispersions_with_Pluronic_F127_prepared_by_the_kneading_method_ L2 - https://www.degruyter.com/document/doi/10.1515/acph-2016-0008 DB - PRIME DP - Unbound Medicine ER -