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Genetic insights into statin-associated diabetes risk.
Curr Opin Lipidol 2016; 27(2):125-30CO

Abstract

PURPOSE OF REVIEW

Meta-analyses of major statin trials have suggested that statin therapy modestly increases the risk of developing diabetes. However, the quality of the data on which these findings are based is not without weaknesses and it has also been unclear whether this effect, if true, is an on-target or off-target effect of statins.

RECENT FINDINGS

In a major Mendelian randomization study of variants in the HMGCR gene, which encodes the protein through which statins exert their effect, two polymorphisms associated with lower LDL-cholesterol were also associated with higher weight, higher waist circumference, higher glucose and higher diabetes risk. These findings correspond with findings from the statin trials. In addition, new observational studies using a genetic risk score for LDL-cholesterol suggest that other pathways linked to LDL-cholesterol metabolism may also affect diabetes risk.

SUMMARY

Genetic studies indicate that the observed effect of statins on diabetes risk in trials is highly likely to be a true on-target effect. Although other recent studies have suggested that genetically determined lower LDL-cholesterol may be linked to diabetes risk, further data from both genetic studies and clinical trials of other LDL-cholesterol lowering agents are needed to confirm or refute this.

Authors+Show Affiliations

aDepartment of Medicine, Imperial College London bInstitute of Cardiovascular Science, University College London cNuffield Department of Population Health, University of Oxford, Oxford, UK.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26959703

Citation

Swerdlow, Daniel I., and David Preiss. "Genetic Insights Into Statin-associated Diabetes Risk." Current Opinion in Lipidology, vol. 27, no. 2, 2016, pp. 125-30.
Swerdlow DI, Preiss D. Genetic insights into statin-associated diabetes risk. Curr Opin Lipidol. 2016;27(2):125-30.
Swerdlow, D. I., & Preiss, D. (2016). Genetic insights into statin-associated diabetes risk. Current Opinion in Lipidology, 27(2), pp. 125-30. doi:10.1097/MOL.0000000000000272.
Swerdlow DI, Preiss D. Genetic Insights Into Statin-associated Diabetes Risk. Curr Opin Lipidol. 2016;27(2):125-30. PubMed PMID: 26959703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic insights into statin-associated diabetes risk. AU - Swerdlow,Daniel I, AU - Preiss,David, PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2016/12/15/medline SP - 125 EP - 30 JF - Current opinion in lipidology JO - Curr. Opin. Lipidol. VL - 27 IS - 2 N2 - PURPOSE OF REVIEW: Meta-analyses of major statin trials have suggested that statin therapy modestly increases the risk of developing diabetes. However, the quality of the data on which these findings are based is not without weaknesses and it has also been unclear whether this effect, if true, is an on-target or off-target effect of statins. RECENT FINDINGS: In a major Mendelian randomization study of variants in the HMGCR gene, which encodes the protein through which statins exert their effect, two polymorphisms associated with lower LDL-cholesterol were also associated with higher weight, higher waist circumference, higher glucose and higher diabetes risk. These findings correspond with findings from the statin trials. In addition, new observational studies using a genetic risk score for LDL-cholesterol suggest that other pathways linked to LDL-cholesterol metabolism may also affect diabetes risk. SUMMARY: Genetic studies indicate that the observed effect of statins on diabetes risk in trials is highly likely to be a true on-target effect. Although other recent studies have suggested that genetically determined lower LDL-cholesterol may be linked to diabetes risk, further data from both genetic studies and clinical trials of other LDL-cholesterol lowering agents are needed to confirm or refute this. SN - 1473-6535 UR - https://www.unboundmedicine.com/medline/citation/26959703/Genetic_insights_into_statin_associated_diabetes_risk_ L2 - http://dx.doi.org/10.1097/MOL.0000000000000272 DB - PRIME DP - Unbound Medicine ER -