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Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age.
Asia Pac J Clin Nutr. 2016; 25(1):62-70.AP

Abstract

BACKGROUND AND OBJECTIVES

Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by >75%. Achieving red cell folate (RCF) or plasma folate (PF) >905 nmol/L and >35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption of folic acid fortified milk increases blood folate concentrations to levels associated with a low risk of NTDs in Singaporean women of childbearing age.

METHODS AND STUDY DESIGN

In this double-blind placebo-controlled trial, 70 non-pregnant women (21-35 y) were randomly assigned to receive fortified milk (FM) powder providing 400 μg folic acid per day or unfortified placebo milk (PM) powder for 12 weeks. Blood samples were collected at baseline and at 6 and 12 weeks.

RESULTS

At 12 weeks, mean (95% CI) RCF and PF concentrations were 376 (240, 512) and 39 (26, 51) nmol/L higher in the FM group compared with the PM group (p<0.001). Of the women receiving FM, 71% (n=25) and 86% (n=30) achieved a RCF and PF associated with a very low risk of NTDs, respectively.

CONCLUSION

Folic acid fortified milk increased blood folate concentrations in women of childbearing age to levels associated with a reduced risk of an NTD-affected pregnancy.

Authors+Show Affiliations

Dietetic & Food Services Department, Changi General Hospital, Singapore.Dietetic & Food Services Department, Changi General Hospital, Singapore.Sprim Advanced Life Sciences Ltd, Singapore.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada.Department of Human Nutrition, University of Otago, Dunedin, New Zealand.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada.Food, Nutrition, and Health, the University of British Columbia, Vancouver, Canada. Email: tim.green@ubc.ca; tigreen@mail.ubc.ca.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26965763

Citation

Cheong, Magdalin, et al. "Folic Acid Fortified Milk Increases Blood Folate to Concentrations Associated With a Very Low Risk of Neural Tube Defects in Singaporean Women of Childbearing Age." Asia Pacific Journal of Clinical Nutrition, vol. 25, no. 1, 2016, pp. 62-70.
Cheong M, Xiao HY, Tay V, et al. Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. Asia Pac J Clin Nutr. 2016;25(1):62-70.
Cheong, M., Xiao, H. Y., Tay, V., Karakochuk, C. D., Liu, Y. A., Harvey, S., Lamers, Y., Houghton, L. A., Kitts, D. D., & Green, T. J. (2016). Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. Asia Pacific Journal of Clinical Nutrition, 25(1), 62-70. https://doi.org/10.6133/apjcn.2016.25.1.08
Cheong M, et al. Folic Acid Fortified Milk Increases Blood Folate to Concentrations Associated With a Very Low Risk of Neural Tube Defects in Singaporean Women of Childbearing Age. Asia Pac J Clin Nutr. 2016;25(1):62-70. PubMed PMID: 26965763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. AU - Cheong,Magdalin, AU - Xiao,Huang Ying, AU - Tay,Vicky, AU - Karakochuk,Crystal D, AU - Liu,Yazheng Amy, AU - Harvey,Sarah, AU - Lamers,Yvonne, AU - Houghton,Lisa A, AU - Kitts,David D, AU - Green,Tim J, PY - 2016/3/12/entrez PY - 2016/3/12/pubmed PY - 2016/5/14/medline SP - 62 EP - 70 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 25 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by >75%. Achieving red cell folate (RCF) or plasma folate (PF) >905 nmol/L and >35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption of folic acid fortified milk increases blood folate concentrations to levels associated with a low risk of NTDs in Singaporean women of childbearing age. METHODS AND STUDY DESIGN: In this double-blind placebo-controlled trial, 70 non-pregnant women (21-35 y) were randomly assigned to receive fortified milk (FM) powder providing 400 μg folic acid per day or unfortified placebo milk (PM) powder for 12 weeks. Blood samples were collected at baseline and at 6 and 12 weeks. RESULTS: At 12 weeks, mean (95% CI) RCF and PF concentrations were 376 (240, 512) and 39 (26, 51) nmol/L higher in the FM group compared with the PM group (p<0.001). Of the women receiving FM, 71% (n=25) and 86% (n=30) achieved a RCF and PF associated with a very low risk of NTDs, respectively. CONCLUSION: Folic acid fortified milk increased blood folate concentrations in women of childbearing age to levels associated with a reduced risk of an NTD-affected pregnancy. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/26965763/Folic_acid_fortified_milk_increases_blood_folate_to_concentrations_associated_with_a_very_low_risk_of_neural_tube_defects_in_Singaporean_women_of_childbearing_age_ L2 - http://apjcn.nhri.org.tw/server/APJCN/25/1/62.pdf DB - PRIME DP - Unbound Medicine ER -