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Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy.

Abstract

Typical treatment plans for attention-deficit/hyperactivity disorder (ADHD) utilize nonpharmacological (behavioral/psychosocial) and/or pharmacological interventions. Limited accessibility to behavioral therapies and concerns over adverse effects of pharmacological treatments prompted research for alternative ADHD therapies such as natural product-derived treatments and nutritional supplements. In this study, we reviewed the herbal preparations and nutritional supplements evaluated in clinical studies as potential ADHD treatments and discussed their performance with regard to safety and efficacy in clinical trials. We also discussed some evidence suggesting that adjunct treatment of these agents (with another botanical agent or pharmacological ADHD treatments) may be a promising approach to treat ADHD. The analysis indicated mixed findings with regard to efficacy of natural product-derived ADHD interventions. Nevertheless, these treatments were considered as a "safer" approach than conventional ADHD medications. More comprehensive and appropriately controlled clinical studies are required to fully ascertain efficacy and safety of natural product-derived ADHD treatments. Studies that replicate encouraging findings on the efficacy of combining botanical agents and nutritional supplements with other natural product-derived therapies and widely used ADHD medications are also warranted. In conclusion, the risk-benefit balance of natural product-derived ADHD treatments should be carefully monitored when used as standalone treatment or when combined with other conventional ADHD treatments.

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  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical and Administrative Sciences, Loma Linda University, Loma Linda, CA 92350, USA.

    ,

    School of Medicine, Chungnam National University, Daejeon 301-747, Republic of Korea.

    ,

    Department of Pharmacy, Sahmyook University, Seoul 139-742, Republic of Korea.

    Department of Pharmaceutical and Administrative Sciences, Loma Linda University, Loma Linda, CA 92350, USA.

    Source

    Neural plasticity 2016: 2016 pg 1320423

    MeSH

    Attention Deficit Disorder with Hyperactivity
    Clinical Trials as Topic
    Complementary Therapies
    Drug Therapy, Combination
    Humans
    Phytotherapy
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26966583

    Citation

    Ahn, James, et al. "Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy." Neural Plasticity, vol. 2016, 2016, p. 1320423.
    Ahn J, Ahn HS, Cheong JH, et al. Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy. Neural Plast. 2016;2016:1320423.
    Ahn, J., Ahn, H. S., Cheong, J. H., & Dela Peña, I. (2016). Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy. Neural Plasticity, 2016, p. 1320423. doi:10.1155/2016/1320423.
    Ahn J, et al. Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy. Neural Plast. 2016;2016:1320423. PubMed PMID: 26966583.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy. AU - Ahn,James, AU - Ahn,Hyung Seok, AU - Cheong,Jae Hoon, AU - Dela Peña,Ike, Y1 - 2016/02/04/ PY - 2015/11/09/received PY - 2015/12/30/revised PY - 2016/01/10/accepted PY - 2016/3/12/entrez PY - 2016/3/12/pubmed PY - 2016/12/15/medline SP - 1320423 EP - 1320423 JF - Neural plasticity JO - Neural Plast. VL - 2016 N2 - Typical treatment plans for attention-deficit/hyperactivity disorder (ADHD) utilize nonpharmacological (behavioral/psychosocial) and/or pharmacological interventions. Limited accessibility to behavioral therapies and concerns over adverse effects of pharmacological treatments prompted research for alternative ADHD therapies such as natural product-derived treatments and nutritional supplements. In this study, we reviewed the herbal preparations and nutritional supplements evaluated in clinical studies as potential ADHD treatments and discussed their performance with regard to safety and efficacy in clinical trials. We also discussed some evidence suggesting that adjunct treatment of these agents (with another botanical agent or pharmacological ADHD treatments) may be a promising approach to treat ADHD. The analysis indicated mixed findings with regard to efficacy of natural product-derived ADHD interventions. Nevertheless, these treatments were considered as a "safer" approach than conventional ADHD medications. More comprehensive and appropriately controlled clinical studies are required to fully ascertain efficacy and safety of natural product-derived ADHD treatments. Studies that replicate encouraging findings on the efficacy of combining botanical agents and nutritional supplements with other natural product-derived therapies and widely used ADHD medications are also warranted. In conclusion, the risk-benefit balance of natural product-derived ADHD treatments should be carefully monitored when used as standalone treatment or when combined with other conventional ADHD treatments. SN - 1687-5443 UR - https://www.unboundmedicine.com/medline/citation/26966583/full_citation L2 - https://dx.doi.org/10.1155/2016/1320423 DB - PRIME DP - Unbound Medicine ER -