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Association between Urinary Sodium Excretion and Bone Health in Male and Female Adults.

Abstract

BACKGROUND

High salt intake is a well-known risk factor for osteoporosis, but the association between bone mass and urinary sodium excretion has not been studied as yet. This study investigates the hypothesis that urinary sodium excretion is negatively associated with bone mass and the risk of osteoporosis.

METHODS

This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey, 2008-2011. Participants (n = 16,279) were divided into age groups; men were categorized as younger than 50 years of age or 50 years or greater, women were categorized as pre- or post-menopausal.

RESULTS

Multivariate linear regression analysis showed that urinary sodium excretion was negatively associated with bone mineral content (BMC) and bone mineral density (BMD) in premenopausal and postmenopausal women. Sodium excretion was negatively associated with BMC and BMD of the lumbar spine in women with normal bone health, osteopenia and osteoporosis, but there was no association in men. Increased sodium excretion was significantly associated with risk for osteoporosis/osteopenia in premenopausal women.

CONCLUSIONS

This study demonstrates that urinary sodium excretion is negatively associated with bone health, suggesting that high salt intake could be a possible risk factor for osteoporosis in Korean women, but not in men.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, Republic of Korea.

    ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Biomarkers
    Bone Density
    Bone Diseases, Metabolic
    Cross-Sectional Studies
    Diet
    Female
    Health Surveys
    Humans
    Male
    Middle Aged
    Osteoporosis
    Osteoporosis, Postmenopausal
    Reproducibility of Results
    Republic of Korea
    Risk Factors
    Sex Factors
    Sodium
    Sodium Chloride, Dietary
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26967579

    Citation

    Park, Yongsoon, et al. "Association Between Urinary Sodium Excretion and Bone Health in Male and Female Adults." Annals of Nutrition & Metabolism, vol. 68, no. 3, 2016, pp. 189-96.
    Park Y, Kwon SJ, Ha YC. Association between Urinary Sodium Excretion and Bone Health in Male and Female Adults. Ann Nutr Metab. 2016;68(3):189-96.
    Park, Y., Kwon, S. J., & Ha, Y. C. (2016). Association between Urinary Sodium Excretion and Bone Health in Male and Female Adults. Annals of Nutrition & Metabolism, 68(3), pp. 189-96. doi:10.1159/000444536.
    Park Y, Kwon SJ, Ha YC. Association Between Urinary Sodium Excretion and Bone Health in Male and Female Adults. Ann Nutr Metab. 2016;68(3):189-96. PubMed PMID: 26967579.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between Urinary Sodium Excretion and Bone Health in Male and Female Adults. AU - Park,Yongsoon, AU - Kwon,Soo Jung, AU - Ha,Yong Chan, Y1 - 2016/03/12/ PY - 2015/06/21/received PY - 2016/02/04/accepted PY - 2016/3/12/entrez PY - 2016/3/12/pubmed PY - 2016/12/31/medline SP - 189 EP - 96 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 68 IS - 3 N2 - BACKGROUND: High salt intake is a well-known risk factor for osteoporosis, but the association between bone mass and urinary sodium excretion has not been studied as yet. This study investigates the hypothesis that urinary sodium excretion is negatively associated with bone mass and the risk of osteoporosis. METHODS: This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey, 2008-2011. Participants (n = 16,279) were divided into age groups; men were categorized as younger than 50 years of age or 50 years or greater, women were categorized as pre- or post-menopausal. RESULTS: Multivariate linear regression analysis showed that urinary sodium excretion was negatively associated with bone mineral content (BMC) and bone mineral density (BMD) in premenopausal and postmenopausal women. Sodium excretion was negatively associated with BMC and BMD of the lumbar spine in women with normal bone health, osteopenia and osteoporosis, but there was no association in men. Increased sodium excretion was significantly associated with risk for osteoporosis/osteopenia in premenopausal women. CONCLUSIONS: This study demonstrates that urinary sodium excretion is negatively associated with bone health, suggesting that high salt intake could be a possible risk factor for osteoporosis in Korean women, but not in men. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/26967579/full_citation L2 - https://www.karger.com?DOI=10.1159/000444536 DB - PRIME DP - Unbound Medicine ER -