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Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies.
BMC Cancer. 2016 Mar 12; 16:212.BC

Abstract

BACKGROUND

Studies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies.

METHODS

We searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95% confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model.

RESULTS

We included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95% CI: 1.06-1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95% CI: 1.17-1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake..

CONCLUSIONS

Low-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer.

Authors+Show Affiliations

Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China.Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China.Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China.Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China.Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, Hefei City, Anhui Province, 230001, China. fanghuayinganhui@126.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26968702

Citation

Wang, Ye-Tao, et al. "Association Between Alcohol Intake and the Risk of Pancreatic Cancer: a Dose-response Meta-analysis of Cohort Studies." BMC Cancer, vol. 16, 2016, p. 212.
Wang YT, Gou YW, Jin WW, et al. Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies. BMC Cancer. 2016;16:212.
Wang, Y. T., Gou, Y. W., Jin, W. W., Xiao, M., & Fang, H. Y. (2016). Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies. BMC Cancer, 16, 212. https://doi.org/10.1186/s12885-016-2241-1
Wang YT, et al. Association Between Alcohol Intake and the Risk of Pancreatic Cancer: a Dose-response Meta-analysis of Cohort Studies. BMC Cancer. 2016 Mar 12;16:212. PubMed PMID: 26968702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies. AU - Wang,Ye-Tao, AU - Gou,Ya-Wen, AU - Jin,Wen-Wen, AU - Xiao,Mei, AU - Fang,Hua-Ying, Y1 - 2016/03/12/ PY - 2014/11/30/received PY - 2016/03/01/accepted PY - 2016/3/13/entrez PY - 2016/3/13/pubmed PY - 2016/12/15/medline KW - Alcohol KW - Meta-analysis KW - Pancreatic cancer SP - 212 EP - 212 JF - BMC cancer JO - BMC Cancer VL - 16 N2 - BACKGROUND: Studies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies. METHODS: We searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95% confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model. RESULTS: We included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95% CI: 1.06-1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95% CI: 1.17-1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake.. CONCLUSIONS: Low-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/26968702/Association_between_alcohol_intake_and_the_risk_of_pancreatic_cancer:_a_dose_response_meta_analysis_of_cohort_studies_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2241-1 DB - PRIME DP - Unbound Medicine ER -