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REM-related sleep-disordered breathing is associated with depressive symptoms in men but not in women.
Sleep Breath. 2016 Sep; 20(3):995-1002.SB

Abstract

PURPOSE

The purposes of the present study are to determine the prevalence and demographic features of rapid eye movement (REM)-related sleep-disordered breathing (SDB) in Korean adults with newly diagnosed obstructive sleep apnea (OSA) and determine if REM-related SDB is associated with depressive symptoms and health-related quality of life (HRQoL) in OSA patients.

METHODS

In this cross-sectional study, we evaluated 1281 OSA adults who were consecutively recruited. REM-related SDB was defined as an overall apnea-hypopnea index (AHI) ≥5, an AHINREM <15, and AHIREM to AHINREM ratio of >2. The Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and Medical Outcomes Study Short-Form Health survey (SF-36) were used to evaluate all patients. Multiple regression analyses were performed to determine the associations between REM-related SDB and clinical outcomes.

RESULTS

The prevalence of REM-related SDB was 18 % in this study. REM-related SDB was more commonly observed in patients with mild or moderate OSA (p < 0.001) and women (p < 0.001). The linear regression analysis showed that the presence of REM-related SDB was significantly associated with higher BDI scores, but only in men. AHIREM was positively associated with the BDI scores, but only in men with REM-related SDB. There were no differences in ESS and SF-36 scores between patients with and without REM-related SDB.

CONCLUSIONS

Patients with REM-related SDB account for 18 % of Korean OSA adults. REM-related SDB was associated with depressive symptoms, but only in men. AHIREM is positively related to the degree of depressive symptoms in men with REM-related SDB.

Authors+Show Affiliations

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea. salee@amc.seoul.kr.Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea.Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26969657

Citation

Lee, Sang-Ahm, et al. "REM-related Sleep-disordered Breathing Is Associated With Depressive Symptoms in Men but Not in Women." Sleep & Breathing = Schlaf & Atmung, vol. 20, no. 3, 2016, pp. 995-1002.
Lee SA, Paek JH, Han SH. REM-related sleep-disordered breathing is associated with depressive symptoms in men but not in women. Sleep Breath. 2016;20(3):995-1002.
Lee, S. A., Paek, J. H., & Han, S. H. (2016). REM-related sleep-disordered breathing is associated with depressive symptoms in men but not in women. Sleep & Breathing = Schlaf & Atmung, 20(3), 995-1002. https://doi.org/10.1007/s11325-016-1323-2
Lee SA, Paek JH, Han SH. REM-related Sleep-disordered Breathing Is Associated With Depressive Symptoms in Men but Not in Women. Sleep Breath. 2016;20(3):995-1002. PubMed PMID: 26969657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - REM-related sleep-disordered breathing is associated with depressive symptoms in men but not in women. AU - Lee,Sang-Ahm, AU - Paek,Joon-Hyun, AU - Han,Su-Hyun, Y1 - 2016/03/11/ PY - 2015/11/12/received PY - 2016/02/15/accepted PY - 2016/01/10/revised PY - 2016/3/13/entrez PY - 2016/3/13/pubmed PY - 2017/10/27/medline KW - Daytime sleepiness KW - Depression KW - Obstructive sleep apnea KW - Quality of life KW - REM related KW - Rapid eye movement KW - Sleep-disordered breathing SP - 995 EP - 1002 JF - Sleep & breathing = Schlaf & Atmung JO - Sleep Breath VL - 20 IS - 3 N2 - PURPOSE: The purposes of the present study are to determine the prevalence and demographic features of rapid eye movement (REM)-related sleep-disordered breathing (SDB) in Korean adults with newly diagnosed obstructive sleep apnea (OSA) and determine if REM-related SDB is associated with depressive symptoms and health-related quality of life (HRQoL) in OSA patients. METHODS: In this cross-sectional study, we evaluated 1281 OSA adults who were consecutively recruited. REM-related SDB was defined as an overall apnea-hypopnea index (AHI) ≥5, an AHINREM <15, and AHIREM to AHINREM ratio of >2. The Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and Medical Outcomes Study Short-Form Health survey (SF-36) were used to evaluate all patients. Multiple regression analyses were performed to determine the associations between REM-related SDB and clinical outcomes. RESULTS: The prevalence of REM-related SDB was 18 % in this study. REM-related SDB was more commonly observed in patients with mild or moderate OSA (p < 0.001) and women (p < 0.001). The linear regression analysis showed that the presence of REM-related SDB was significantly associated with higher BDI scores, but only in men. AHIREM was positively associated with the BDI scores, but only in men with REM-related SDB. There were no differences in ESS and SF-36 scores between patients with and without REM-related SDB. CONCLUSIONS: Patients with REM-related SDB account for 18 % of Korean OSA adults. REM-related SDB was associated with depressive symptoms, but only in men. AHIREM is positively related to the degree of depressive symptoms in men with REM-related SDB. SN - 1522-1709 UR - https://www.unboundmedicine.com/medline/citation/26969657/REM_related_sleep_disordered_breathing_is_associated_with_depressive_symptoms_in_men_but_not_in_women_ L2 - https://dx.doi.org/10.1007/s11325-016-1323-2 DB - PRIME DP - Unbound Medicine ER -