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[Ranitidine protects the human stomach and duodenal mucosa against low-dose acetylsalicylic acid].
Z Gastroenterol. 1989 Dec; 27(12):722-4.ZG

Abstract

In a randomized double-blind study the gastroduodenal tolerability of 300 mg ASS daily has been evaluated in the presence of 150 mg ranitidine bid or placebo in 20 healthy volunteers using upper GI-endoscopy. The treatment period lasted 14 days. Endoscopic controls were performed at entry, and repeated at day 7 and day 14. At entry, the mean endoscopic score averaged 0.8 +/- 0.1 in the ASS/placebo-group and 1.0 +/- 0.0 in the ASS/ranitidine group. 300 mg ASS daily induced in the placebo experiments marked gastroduodenal alterations both at day 7 and day 14 (4.7 +/- 1.2 and 6.5 +/- 2.1, respectively). Concomitant administration of 150 mg ranitidine bid afforded almost full protection against 300 mg ASS daily both on day 7 and day 14 (1.9 +/- 0.6 and 2.1 +/- 0.8, respectively) (p less than 0.05). Our data suggest that coadministration of ranitidine 150 mg bid reduces almost completely gastroduodenal lesions evoked by acetylsalicylic acid 300 mg daily.

Authors+Show Affiliations

Müller P
Medizinische Universitätsklinik, Gastroenterologische Abteilung, Heidelberg.
Damman HG
No affiliation info available
Marinis E
No affiliation info available
Simon B
No affiliation info available

MeSH

AdultAspirinDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationGastric MucosaGastritisGastrointestinal HemorrhageGastroscopyHumansMaleRandomized Controlled Trials as TopicRanitidine

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

2697116

Citation

Müller, P, et al. "[Ranitidine Protects the Human Stomach and Duodenal Mucosa Against Low-dose Acetylsalicylic Acid]." Zeitschrift Fur Gastroenterologie, vol. 27, no. 12, 1989, pp. 722-4.
Müller P, Damman HG, Marinis E, et al. [Ranitidine protects the human stomach and duodenal mucosa against low-dose acetylsalicylic acid]. Z Gastroenterol. 1989;27(12):722-4.
Müller, P., Damman, H. G., Marinis, E., & Simon, B. (1989). [Ranitidine protects the human stomach and duodenal mucosa against low-dose acetylsalicylic acid]. Zeitschrift Fur Gastroenterologie, 27(12), 722-4.
Müller P, et al. [Ranitidine Protects the Human Stomach and Duodenal Mucosa Against Low-dose Acetylsalicylic Acid]. Z Gastroenterol. 1989;27(12):722-4. PubMed PMID: 2697116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Ranitidine protects the human stomach and duodenal mucosa against low-dose acetylsalicylic acid]. AU - Müller,P, AU - Damman,H G, AU - Marinis,E, AU - Simon,B, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 722 EP - 4 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 27 IS - 12 N2 - In a randomized double-blind study the gastroduodenal tolerability of 300 mg ASS daily has been evaluated in the presence of 150 mg ranitidine bid or placebo in 20 healthy volunteers using upper GI-endoscopy. The treatment period lasted 14 days. Endoscopic controls were performed at entry, and repeated at day 7 and day 14. At entry, the mean endoscopic score averaged 0.8 +/- 0.1 in the ASS/placebo-group and 1.0 +/- 0.0 in the ASS/ranitidine group. 300 mg ASS daily induced in the placebo experiments marked gastroduodenal alterations both at day 7 and day 14 (4.7 +/- 1.2 and 6.5 +/- 2.1, respectively). Concomitant administration of 150 mg ranitidine bid afforded almost full protection against 300 mg ASS daily both on day 7 and day 14 (1.9 +/- 0.6 and 2.1 +/- 0.8, respectively) (p less than 0.05). Our data suggest that coadministration of ranitidine 150 mg bid reduces almost completely gastroduodenal lesions evoked by acetylsalicylic acid 300 mg daily. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/2697116/[Ranitidine_protects_the_human_stomach_and_duodenal_mucosa_against_low_dose_acetylsalicylic_acid]_ L2 - https://medlineplus.gov/gastrointestinalbleeding.html DB - PRIME DP - Unbound Medicine ER -