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Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012.
J Dtsch Dermatol Ges. 2016 Mar; 14(3):277-84.JD

Abstract

BACKGROUND

Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown pathophysiology. Its potential association with diabetes mellitus is well known. Other relevant cofactors and comorbidities are subject to controversial debate.

PATIENTS AND METHODS

DRG (diagnosis-related groups) data of all inpatients with a coded primary or secondary diagnosis of NL treated at German hospitals in 2012 were evaluated.

RESULTS

Data of 262 inpatient cases with the primary or secondary diagnosis of NL were analyzed. Women (63.4%; n = 166) were nearly twice as frequently affected as men (36.2%; n = 96). Most NL patients (14.8%) were in the age group between 50 and 55 years. Among comorbidities included in the metabolic syndrome complex, diabetes mellitus was the most common (34.4%; IDDM 20.6%, NIDDM 13.8%), while essential hypertension was observed in 9.2%, obesity in 4.6%, chronic heart failure in 4.1%, and dyslipidemias in 2.3% of cases. Leg ulcers were diagnosed in 7.3% of individuals; other venous disorders, in 5.7%.

CONCLUSIONS

Our data analysis describes one of the largest compilations of patient cases with the diagnosis of NL worldwide. Besides the well-known association with diabetes mellitus, there are numerous other potentially relevant cofactors and comorbidities that should be considered in the diagnosis and management of NL patients.

Authors+Show Affiliations

Department of Dermatology, Venereology, and Allergology, University Hospital Essen, Essen, Germany.Division of of Angiology, Helios Hospital, Krefeld, Germany.Department of Dermatology, Venereology, and Allergology, University Hospital Essen, Essen, Germany.Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.Department of Dermatology, Venereology, and Allergology, University Hospital Essen, Essen, Germany.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26972191

Citation

Jockenhöfer, Finja, et al. "Cofactors and Comorbidities of Necrobiosis Lipoidica: Analysis of the German DRG Data From 2012." Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, vol. 14, no. 3, 2016, pp. 277-84.
Jockenhöfer F, Kröger K, Klode J, et al. Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. J Dtsch Dermatol Ges. 2016;14(3):277-84.
Jockenhöfer, F., Kröger, K., Klode, J., Renner, R., Erfurt-Berge, C., & Dissemond, J. (2016). Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 14(3), 277-84. https://doi.org/10.1111/ddg.12749
Jockenhöfer F, et al. Cofactors and Comorbidities of Necrobiosis Lipoidica: Analysis of the German DRG Data From 2012. J Dtsch Dermatol Ges. 2016;14(3):277-84. PubMed PMID: 26972191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. AU - Jockenhöfer,Finja, AU - Kröger,Knut, AU - Klode,Joachim, AU - Renner,Regina, AU - Erfurt-Berge,Cornelia, AU - Dissemond,Joachim, PY - 2016/3/15/entrez PY - 2016/3/15/pubmed PY - 2016/12/23/medline KW - DRG data KW - Necrobiosis lipoidica KW - cofactors KW - comorbidities KW - diabetes mellitus KW - leg ulcers SP - 277 EP - 84 JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG JO - J Dtsch Dermatol Ges VL - 14 IS - 3 N2 - BACKGROUND: Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown pathophysiology. Its potential association with diabetes mellitus is well known. Other relevant cofactors and comorbidities are subject to controversial debate. PATIENTS AND METHODS: DRG (diagnosis-related groups) data of all inpatients with a coded primary or secondary diagnosis of NL treated at German hospitals in 2012 were evaluated. RESULTS: Data of 262 inpatient cases with the primary or secondary diagnosis of NL were analyzed. Women (63.4%; n = 166) were nearly twice as frequently affected as men (36.2%; n = 96). Most NL patients (14.8%) were in the age group between 50 and 55 years. Among comorbidities included in the metabolic syndrome complex, diabetes mellitus was the most common (34.4%; IDDM 20.6%, NIDDM 13.8%), while essential hypertension was observed in 9.2%, obesity in 4.6%, chronic heart failure in 4.1%, and dyslipidemias in 2.3% of cases. Leg ulcers were diagnosed in 7.3% of individuals; other venous disorders, in 5.7%. CONCLUSIONS: Our data analysis describes one of the largest compilations of patient cases with the diagnosis of NL worldwide. Besides the well-known association with diabetes mellitus, there are numerous other potentially relevant cofactors and comorbidities that should be considered in the diagnosis and management of NL patients. SN - 1610-0387 UR - https://www.unboundmedicine.com/medline/citation/26972191/Cofactors_and_comorbidities_of_necrobiosis_lipoidica:_analysis_of_the_German_DRG_data_from_2012_ L2 - https://doi.org/10.1111/ddg.12749 DB - PRIME DP - Unbound Medicine ER -