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Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities.
Carbohydr Res. 2016 Apr 07; 424:30-41.CR

Abstract

Mushrooms are popular folk medicines that have attracted considerable attention because of their efficient antitumor activities. This review covers existing research achievements on the mechanisms of isolated mushroom polysaccharides, particularly (1→3)-β-D-glucans. Our review also describes the function in modulating the immune system and potential tumor-inhibitory effects of polysaccharides. The antitumor mechanisms of mushroom polysaccharides are mediated by stimulated T cells or other immune cells. These polysaccharides are able to trigger various cellular responses, such as the expression of cytokines and nitric oxide. Most polysaccharides could bind other conjugate molecules, such as polypeptides and proteins, whose conjugation always possess strong antitumor activities. The purpose of this review is to summarize available information, and to reflect the present situation of polysaccharide research filed with a view for future direction.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Meng X
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China.
Liang H
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China.
Luo L
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China. Electronic address: btlxluo@scut.edu.cn.

MeSH

Adjuvants, ImmunologicAgaricalesAntineoplastic AgentsCarbohydrate ConformationHumansImmunomodulationNeoplasmsPolysaccharides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26974354

Citation

Meng, Xin, et al. "Antitumor Polysaccharides From Mushrooms: a Review On the Structural Characteristics, Antitumor Mechanisms and Immunomodulating Activities." Carbohydrate Research, vol. 424, 2016, pp. 30-41.
Meng X, Liang H, Luo L. Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydr Res. 2016;424:30-41.
Meng, X., Liang, H., & Luo, L. (2016). Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydrate Research, 424, 30-41. https://doi.org/10.1016/j.carres.2016.02.008
Meng X, Liang H, Luo L. Antitumor Polysaccharides From Mushrooms: a Review On the Structural Characteristics, Antitumor Mechanisms and Immunomodulating Activities. Carbohydr Res. 2016 Apr 7;424:30-41. PubMed PMID: 26974354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. AU - Meng,Xin, AU - Liang,Hebin, AU - Luo,Lixin, Y1 - 2016/03/02/ PY - 2015/11/24/received PY - 2016/02/22/revised PY - 2016/02/23/accepted PY - 2016/3/15/entrez PY - 2016/3/15/pubmed PY - 2016/12/15/medline KW - Antitumor KW - Folk medicine KW - Mechanism KW - Mushroom polysaccharide SP - 30 EP - 41 JF - Carbohydrate research JO - Carbohydr Res VL - 424 N2 - Mushrooms are popular folk medicines that have attracted considerable attention because of their efficient antitumor activities. This review covers existing research achievements on the mechanisms of isolated mushroom polysaccharides, particularly (1→3)-β-D-glucans. Our review also describes the function in modulating the immune system and potential tumor-inhibitory effects of polysaccharides. The antitumor mechanisms of mushroom polysaccharides are mediated by stimulated T cells or other immune cells. These polysaccharides are able to trigger various cellular responses, such as the expression of cytokines and nitric oxide. Most polysaccharides could bind other conjugate molecules, such as polypeptides and proteins, whose conjugation always possess strong antitumor activities. The purpose of this review is to summarize available information, and to reflect the present situation of polysaccharide research filed with a view for future direction. SN - 1873-426X UR - https://www.unboundmedicine.com/medline/citation/26974354/Antitumor_polysaccharides_from_mushrooms:_a_review_on_the_structural_characteristics_antitumor_mechanisms_and_immunomodulating_activities_ DB - PRIME DP - Unbound Medicine ER -