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Roll compaction/dry granulation: Suitability of different binders.
Int J Pharm. 2016 Apr 30; 503(1-2):213-9.IJ

Abstract

As dry granulation as a continuous process becomes steadily more important, the interest of different materials and their processing is growing. Binders are of high importance as they have to compensate granule hardening, reduce the fines, and ensure adequate tablet tensile strengths. A simple formulation was used for roll compaction/dry granulation with subsequent tableting to produce granules and tablets, containing paracetamol (70% w/w), a filler and a binder (10%). With this formulation other influences were negligible and the influence of the binder was almost isolated. Eight different binders were compared with special attention to raw material properties. Six of them were cellulose based and two of them were based on povidone. Granule size distributions were typically bimodal. With the same method of preparation, large differences between the formulations occurred. The median particle size of granules differed from 200 μm, up to barely 700 μm. The larger the resulted particles, the higher was the tensile strength after tableting. Tablets with fine grades of HPC and copovidone achieved highest tensile strength exceeding 2.5 MPa at a compaction pressure of 350 MPa. Formulations with other binders were inferior, but mostly adequate. MCC performed insufficient and led to capping.

Authors+Show Affiliations

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetsstr. 1, 40225 Duesseldorf, Germany.Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetsstr. 1, 40225 Duesseldorf, Germany.Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address: Kleinebudde@hhu.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26976499

Citation

Mangal, Haress, et al. "Roll Compaction/dry Granulation: Suitability of Different Binders." International Journal of Pharmaceutics, vol. 503, no. 1-2, 2016, pp. 213-9.
Mangal H, Kirsolak M, Kleinebudde P. Roll compaction/dry granulation: Suitability of different binders. Int J Pharm. 2016;503(1-2):213-9.
Mangal, H., Kirsolak, M., & Kleinebudde, P. (2016). Roll compaction/dry granulation: Suitability of different binders. International Journal of Pharmaceutics, 503(1-2), 213-9. https://doi.org/10.1016/j.ijpharm.2016.03.015
Mangal H, Kirsolak M, Kleinebudde P. Roll Compaction/dry Granulation: Suitability of Different Binders. Int J Pharm. 2016 Apr 30;503(1-2):213-9. PubMed PMID: 26976499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roll compaction/dry granulation: Suitability of different binders. AU - Mangal,Haress, AU - Kirsolak,Mehmet, AU - Kleinebudde,Peter, Y1 - 2016/03/11/ PY - 2016/02/02/received PY - 2016/03/08/revised PY - 2016/03/09/accepted PY - 2016/3/16/entrez PY - 2016/3/16/pubmed PY - 2017/1/4/medline KW - Dry binder KW - Granule size distribution KW - Particle size KW - Roll compaction/dry granulation KW - Tabletability SP - 213 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 503 IS - 1-2 N2 - As dry granulation as a continuous process becomes steadily more important, the interest of different materials and their processing is growing. Binders are of high importance as they have to compensate granule hardening, reduce the fines, and ensure adequate tablet tensile strengths. A simple formulation was used for roll compaction/dry granulation with subsequent tableting to produce granules and tablets, containing paracetamol (70% w/w), a filler and a binder (10%). With this formulation other influences were negligible and the influence of the binder was almost isolated. Eight different binders were compared with special attention to raw material properties. Six of them were cellulose based and two of them were based on povidone. Granule size distributions were typically bimodal. With the same method of preparation, large differences between the formulations occurred. The median particle size of granules differed from 200 μm, up to barely 700 μm. The larger the resulted particles, the higher was the tensile strength after tableting. Tablets with fine grades of HPC and copovidone achieved highest tensile strength exceeding 2.5 MPa at a compaction pressure of 350 MPa. Formulations with other binders were inferior, but mostly adequate. MCC performed insufficient and led to capping. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/26976499/Roll_compaction/dry_granulation:_Suitability_of_different_binders_ DB - PRIME DP - Unbound Medicine ER -