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Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance.
Anticancer Res. 2016 Mar; 36(3):1295-303.AR

Abstract

AIM

Ran binding protein M (RanBPM) is a ubiquitous, nucleocytoplasmic protein that serves as a scaffolding molecule. This study aimed to investigate the role of RanBPM in gastric cancer.

MATERIALS AND METHODS

RanBPM expression in human gastric cancer tissue samples was analyzed using real-time polymerase chain reaction. The effect of RanBPM on cellular functions was examined in RanBPM-knockdown gastric cells and with in vitro cell functional assays.

RESULTS

Gastric tumors with distant metastases expressed lower levels of RanBPM transcripts compared to tumours without detectable metastases (p=0.036). RanBPM knockdown in gastric cancer cells reduced adhesion and promoted survival of gastric cancer cells after exposure to methotrexate and fluorouracil.

CONCLUSION

RanBPM levels were reduced in gastric tumors with distant metastases. This suggests that loss of RanBPM expression may play an important role in gastric cancer tumor development and metastasis. Reduced RanBPM expression is also associated with chemoresistance of gastric cancer cells.

Authors+Show Affiliations

Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K. Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Tumor Center, Peking University Cancer Hospital and Institute, Beijing, P.R. China.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Tumor Center, Peking University Cancer Hospital and Institute, Beijing, P.R. China.Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Tumor Center, Peking University Cancer Hospital and Institute, Beijing, P.R. China.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K.Metastasis & Angiogenesis Research Group, Cardiff-China Medical Research Collaborative (CCMRC), Division of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, U.K. YeL@cf.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26977028

Citation

Shao, Shuai, et al. "Reduced RanBPM Expression Is Associated With Distant Metastasis in Gastric Cancer and Chemoresistance." Anticancer Research, vol. 36, no. 3, 2016, pp. 1295-303.
Shao S, Sun PH, Satherley LK, et al. Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance. Anticancer Res. 2016;36(3):1295-303.
Shao, S., Sun, P. H., Satherley, L. K., Gao, X., Ji, K. E., Feng, Y. I., Jia, Y., Ji, J., Jiang, W. G., & Ye, L. (2016). Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance. Anticancer Research, 36(3), 1295-303.
Shao S, et al. Reduced RanBPM Expression Is Associated With Distant Metastasis in Gastric Cancer and Chemoresistance. Anticancer Res. 2016;36(3):1295-303. PubMed PMID: 26977028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance. AU - Shao,Shuai, AU - Sun,Ping-Hui, AU - Satherley,Lucy K, AU - Gao,Xiangyu, AU - Ji,K E, AU - Feng,Y I, AU - Jia,Yongning, AU - Ji,Jiafu, AU - Jiang,Wen G, AU - Ye,Lin, PY - 2016/3/16/entrez PY - 2016/3/16/pubmed PY - 2016/11/8/medline KW - RanBPM KW - gastric cancer KW - growth KW - invasion KW - matrix metalloproteinase KW - migration SP - 1295 EP - 303 JF - Anticancer research JO - Anticancer Res VL - 36 IS - 3 N2 - AIM: Ran binding protein M (RanBPM) is a ubiquitous, nucleocytoplasmic protein that serves as a scaffolding molecule. This study aimed to investigate the role of RanBPM in gastric cancer. MATERIALS AND METHODS: RanBPM expression in human gastric cancer tissue samples was analyzed using real-time polymerase chain reaction. The effect of RanBPM on cellular functions was examined in RanBPM-knockdown gastric cells and with in vitro cell functional assays. RESULTS: Gastric tumors with distant metastases expressed lower levels of RanBPM transcripts compared to tumours without detectable metastases (p=0.036). RanBPM knockdown in gastric cancer cells reduced adhesion and promoted survival of gastric cancer cells after exposure to methotrexate and fluorouracil. CONCLUSION: RanBPM levels were reduced in gastric tumors with distant metastases. This suggests that loss of RanBPM expression may play an important role in gastric cancer tumor development and metastasis. Reduced RanBPM expression is also associated with chemoresistance of gastric cancer cells. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/26977028/Reduced_RanBPM_Expression_Is_Associated_with_Distant_Metastasis_in_Gastric_Cancer_and_Chemoresistance_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=26977028 DB - PRIME DP - Unbound Medicine ER -