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Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation.
Anticancer Res. 2016 Mar; 36(3):1397-401.AR

Abstract

BACKGROUND

In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients.

PATIENTS AND METHODS

Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed.

RESULTS

With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold.

CONCLUSION

Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D.

Authors+Show Affiliations

Department of Natural Medicine, Research Group of Medical Heliotherapy, Charité - University Medicine Berlin and Immanuel Hospital, Berlin, Germany Nephrological Center Moabit, Curatorium for Dialysis and Kidney Transplantation, Berlin, Germany rolfdieter.krause@t-online.de.Department of Endocrinology, Limbach Laboratory, Heidelberg, Germany.Institute of Lighting Technics, Technical University Berlin, Berlin, Germany.Department of Natural Medicine, Research Group of Medical Heliotherapy, Charité - University Medicine Berlin and Immanuel Hospital, Berlin, Germany.Department of Endocrinology, Vitamin D Research Laboratory, School of Medicine Boston University, Boston, MA, U.S.A.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26977042

Citation

Krause, Rolfdieter, et al. "Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation." Anticancer Research, vol. 36, no. 3, 2016, pp. 1397-401.
Krause R, Roth HJ, Kaase H, et al. Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation. Anticancer Res. 2016;36(3):1397-401.
Krause, R., Roth, H. J., Kaase, H., Stange, R., & Holick, M. F. (2016). Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation. Anticancer Research, 36(3), 1397-401.
Krause R, et al. Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation. Anticancer Res. 2016;36(3):1397-401. PubMed PMID: 26977042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation. AU - Krause,Rolfdieter, AU - Roth,Heinz Jürgen, AU - Kaase,Heinrich, AU - Stange,Rainer, AU - Holick,Michael F, PY - 2016/3/16/entrez PY - 2016/3/16/pubmed PY - 2016/7/28/medline KW - 1,25-dihydroxyvitamin D KW - 1-alpha-hydroxylase KW - 25-hydroxyvitamin D KW - UVB irradiation KW - Vitamin D KW - chronic kidney disease (CKD) KW - dialysis (ESKD) KW - extra-renal synthesis KW - oral supplementation KW - vitamin D receptor SP - 1397 EP - 401 JF - Anticancer research JO - Anticancer Res VL - 36 IS - 3 N2 - BACKGROUND: In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients. PATIENTS AND METHODS: Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed. RESULTS: With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold. CONCLUSION: Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/26977042/Vitamin_D_Status_in_Chronic_Kidney_Disease___UVB_Irradiation_Is_Superior_to_Oral_Supplementation_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=26977042 DB - PRIME DP - Unbound Medicine ER -