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L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice.
Neuroreport. 2016 May 04; 27(7):476-80.N

Abstract

Chronic pain is categorized as inflammatory and neuropathic, and there are common mechanisms underlying the generation of each pain state. Such pain is difficult to treat and the treatment at present is inadequate. Corydalis yanhusuo is a traditional Chinese medicine with demonstrated analgesic efficacy in humans. The potential antihyperalgesic effect of its active component is L-tetrahydropalmatine (L-THP). L-THP has been used for the treatment of headache and other mild pain. However, little is known about its analgesic effect on chronic pain and its mechanism. Here, we report that L-THP exerts remarkable antihyperalgesic effects on neuropathic and inflammatory pain in animal models. Neuropathic hypersensitivity was induced by segmental spinal nerve ligation and inflammatory hypersensitivity was induced by an intraplantar injection of complete Freund's adjuvant. To determine the receptor mechanism underlying the antihyperalgesic actions of L-THP, we used SCH23390, an antagonist of a dopamine D1 receptor, in an attempt to block the antihyperalgesic effects of L-THP. We found that L-THP (1-4 mg/kg, i.p.) produced a dose-dependent antihyperalgesic effect in spinal nerve ligation and complete Freund's adjuvant models. The antihyperalgesic effects of L-THP were abolished by a dopamine D1 receptor antagonist SCH23390 (0.02 mg/kg). Furthermore, L-THP (4 mg/kg, i.p.) did not influence motor function. These findings suggest that L-THP may ameliorate mechanical hyperalgesia by enhancing dopamine D1 receptor-mediated dopaminergic transmission.

Authors+Show Affiliations

aDepartment of Pharmacy, Division of Clinical Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing bDepartment of Pharmacy, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin cDepartment of Pharmacy, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26981712

Citation

Zhou, Hai-Hui, et al. "L-Tetrahydropalmatine Alleviates Mechanical Hyperalgesia in Models of Chronic Inflammatory and Neuropathic Pain in Mice." Neuroreport, vol. 27, no. 7, 2016, pp. 476-80.
Zhou HH, Wu DL, Gao LY, et al. L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Neuroreport. 2016;27(7):476-80.
Zhou, H. H., Wu, D. L., Gao, L. Y., Fang, Y., & Ge, W. H. (2016). L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Neuroreport, 27(7), 476-80. https://doi.org/10.1097/WNR.0000000000000560
Zhou HH, et al. L-Tetrahydropalmatine Alleviates Mechanical Hyperalgesia in Models of Chronic Inflammatory and Neuropathic Pain in Mice. Neuroreport. 2016 May 4;27(7):476-80. PubMed PMID: 26981712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. AU - Zhou,Hai-Hui, AU - Wu,Dan-Lian, AU - Gao,Li-Yan, AU - Fang,Yun, AU - Ge,Wei-Hong, PY - 2016/3/17/entrez PY - 2016/3/17/pubmed PY - 2016/12/21/medline SP - 476 EP - 80 JF - Neuroreport JO - Neuroreport VL - 27 IS - 7 N2 - Chronic pain is categorized as inflammatory and neuropathic, and there are common mechanisms underlying the generation of each pain state. Such pain is difficult to treat and the treatment at present is inadequate. Corydalis yanhusuo is a traditional Chinese medicine with demonstrated analgesic efficacy in humans. The potential antihyperalgesic effect of its active component is L-tetrahydropalmatine (L-THP). L-THP has been used for the treatment of headache and other mild pain. However, little is known about its analgesic effect on chronic pain and its mechanism. Here, we report that L-THP exerts remarkable antihyperalgesic effects on neuropathic and inflammatory pain in animal models. Neuropathic hypersensitivity was induced by segmental spinal nerve ligation and inflammatory hypersensitivity was induced by an intraplantar injection of complete Freund's adjuvant. To determine the receptor mechanism underlying the antihyperalgesic actions of L-THP, we used SCH23390, an antagonist of a dopamine D1 receptor, in an attempt to block the antihyperalgesic effects of L-THP. We found that L-THP (1-4 mg/kg, i.p.) produced a dose-dependent antihyperalgesic effect in spinal nerve ligation and complete Freund's adjuvant models. The antihyperalgesic effects of L-THP were abolished by a dopamine D1 receptor antagonist SCH23390 (0.02 mg/kg). Furthermore, L-THP (4 mg/kg, i.p.) did not influence motor function. These findings suggest that L-THP may ameliorate mechanical hyperalgesia by enhancing dopamine D1 receptor-mediated dopaminergic transmission. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/26981712/L_Tetrahydropalmatine_alleviates_mechanical_hyperalgesia_in_models_of_chronic_inflammatory_and_neuropathic_pain_in_mice_ L2 - https://doi.org/10.1097/WNR.0000000000000560 DB - PRIME DP - Unbound Medicine ER -