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Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats.
Int J Food Sci Nutr. 2016 Jun; 67(4):441-53.IJ

Abstract

Phytosterols (P) and fish-oil (F) efficacy on high-oleic-sunflower oil (HOSO) diets were assessed in hypercholesterolemic growing rats. Controls (C) received a standard diet for 8 weeks; experimental rats were fed an atherogenic diet (AT) for 3 weeks, thereafter were divided into four groups fed for 5 weeks a monounsaturated fatty acid diet (MUFA) containing either: extra virgin olive oil (OO), HOSO or HOSO supplemented with P or F. The diets did not alter body weight or growth. HOSO-P and HOSO-F rats showed reduced total cholesterol (T-chol), non-high-density lipoprotein-cholesterol (non-HDL-chol) and triglycerides and increased HDL-chol levels, comparably to the OO rats. Total body fat (%) was similar among all rats; but HOSO-F showed the lowest intestinal, epididymal and perirenal fat. However, bone mineral content and density, and bone yield stress and modulus of elasticity were unchanged. Growing hypercholesterolemic rats fed HOSO with P or F improved serum lipids and fat distribution, but did not influence material bone quality.

Authors+Show Affiliations

a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;b Pediatric Sunshine Academics Inc , Santa Barbara , CA , USA ;c Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;c Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;d Department of General and Oral Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26983467

Citation

Alsina, Estefania, et al. "Efficacy of Phytosterols and Fish-oil Supplemented High-oleic-sunflower Oil Rich Diets in Hypercholesterolemic Growing Rats." International Journal of Food Sciences and Nutrition, vol. 67, no. 4, 2016, pp. 441-53.
Alsina E, Macri EV, Lifshitz F, et al. Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats. Int J Food Sci Nutr. 2016;67(4):441-53.
Alsina, E., Macri, E. V., Lifshitz, F., Bozzini, C., Rodriguez, P. N., Boyer, P. M., & Friedman, S. M. (2016). Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats. International Journal of Food Sciences and Nutrition, 67(4), 441-53. https://doi.org/10.3109/09637486.2016.1161010
Alsina E, et al. Efficacy of Phytosterols and Fish-oil Supplemented High-oleic-sunflower Oil Rich Diets in Hypercholesterolemic Growing Rats. Int J Food Sci Nutr. 2016;67(4):441-53. PubMed PMID: 26983467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats. AU - Alsina,Estefania, AU - Macri,Elisa V, AU - Lifshitz,Fima, AU - Bozzini,Clarisa, AU - Rodriguez,Patricia N, AU - Boyer,Patricia M, AU - Friedman,Silvia M, Y1 - 2016/03/17/ PY - 2016/3/18/entrez PY - 2016/3/18/pubmed PY - 2017/1/14/medline KW - Body fat KW - bone quality KW - fish oil KW - high-oleic-sunflower oil KW - lipid profile KW - phytosterol KW - weight and growth gain SP - 441 EP - 53 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 67 IS - 4 N2 - Phytosterols (P) and fish-oil (F) efficacy on high-oleic-sunflower oil (HOSO) diets were assessed in hypercholesterolemic growing rats. Controls (C) received a standard diet for 8 weeks; experimental rats were fed an atherogenic diet (AT) for 3 weeks, thereafter were divided into four groups fed for 5 weeks a monounsaturated fatty acid diet (MUFA) containing either: extra virgin olive oil (OO), HOSO or HOSO supplemented with P or F. The diets did not alter body weight or growth. HOSO-P and HOSO-F rats showed reduced total cholesterol (T-chol), non-high-density lipoprotein-cholesterol (non-HDL-chol) and triglycerides and increased HDL-chol levels, comparably to the OO rats. Total body fat (%) was similar among all rats; but HOSO-F showed the lowest intestinal, epididymal and perirenal fat. However, bone mineral content and density, and bone yield stress and modulus of elasticity were unchanged. Growing hypercholesterolemic rats fed HOSO with P or F improved serum lipids and fat distribution, but did not influence material bone quality. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/26983467/Efficacy_of_phytosterols_and_fish_oil_supplemented_high_oleic_sunflower_oil_rich_diets_in_hypercholesterolemic_growing_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/09637486.2016.1161010 DB - PRIME DP - Unbound Medicine ER -