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An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals.
Intern Med. 2016; 55(6):699-702.IM

Abstract

Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis.

Authors+Show Affiliations

Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26984094

Citation

Numa, Soichiro, et al. "An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals." Internal Medicine (Tokyo, Japan), vol. 55, no. 6, 2016, pp. 699-702.
Numa S, Kasai T, Kondo T, et al. An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. Intern Med. 2016;55(6):699-702.
Numa, S., Kasai, T., Kondo, T., Kushimura, Y., Kimura, A., Takahashi, H., Morita, K., Tanaka, A., Noto, Y., Ohara, T., Nakagawa, M., & Mizuno, T. (2016). An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. Internal Medicine (Tokyo, Japan), 55(6), 699-702. https://doi.org/10.2169/internalmedicine.55.5727
Numa S, et al. An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. Intern Med. 2016;55(6):699-702. PubMed PMID: 26984094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals. AU - Numa,Soichiro, AU - Kasai,Takashi, AU - Kondo,Takayuki, AU - Kushimura,Yukie, AU - Kimura,Ayaka, AU - Takahashi,Hisashi, AU - Morita,Kanako, AU - Tanaka,Akihiro, AU - Noto,Yu-Ichi, AU - Ohara,Tomoyuki, AU - Nakagawa,Masanori, AU - Mizuno,Toshiki, Y1 - 2016/03/15/ PY - 2016/3/18/entrez PY - 2016/3/18/pubmed PY - 2016/10/12/medline SP - 699 EP - 702 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 55 IS - 6 N2 - Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/26984094/An_Adult_Case_of_Anti_Myelin_Oligodendrocyte_Glycoprotein__MOG__Antibody_associated_Multiphasic_Acute_Disseminated_Encephalomyelitis_at_33_year_Intervals_ L2 - https://dx.doi.org/10.2169/internalmedicine.55.5727 DB - PRIME DP - Unbound Medicine ER -