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Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus.
Rev Neurol 2016; 62(7):317-28RN

Abstract

INTRODUCTION

The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed.

DEVELOPMENT

Since 2007, 55 countries in America, Asia, Africa and Oceania have detected local transmission of the virus. This epidemic has affected almost 1.5 million people in Brazil. 80% of the cases are asymptomatic. The symptoms of Zika virus disease include fever, maculopapular rash, arthralgia and non-purulent conjunctivitis. The symptoms are usually self-limiting and last one week. An increase in the incidence of cases of microcephaly, retinal lesions and Guillain-Barre syndrome associated with the Zika virus has been reported. Zika-associated Guillain-Barre syndrome in Polynesia is a pure motor axonal variant. The RNA of the Zika virus has been identified in samples of brain tissue, placenta and amniotic liquid of children with microcephaly and in the still-born infants of women infected by Zika during pregnancy. The reverse transcription polymerase chain reaction test is recommended to detect viral RNA, and serological tests (IgM ELISA and neutralising antibodies) should be conducted to confirm infection by Zika. The differential diagnosis includes infection by the dengue and chikungunya viruses.

CONCLUSIONS

Knowledge about the pathogenic mechanisms involved in infection due to Zika virus and its long-term consequences in adults and newborn infants is still limited.

Authors+Show Affiliations

Raigmore Hospital, Inverness, Reino Unido.

Pub Type(s)

Journal Article
Review

Language

eng spa

PubMed ID

26988170

Citation

Carod-Artal, Francisco J.. "Epidemiology and Neurological Complications of Infection By the Zika Virus: a New Emerging Neurotropic Virus." Revista De Neurologia, vol. 62, no. 7, 2016, pp. 317-28.
Carod-Artal FJ. Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus. Rev Neurol. 2016;62(7):317-28.
Carod-Artal, F. J. (2016). Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus. Revista De Neurologia, 62(7), pp. 317-28.
Carod-Artal FJ. Epidemiology and Neurological Complications of Infection By the Zika Virus: a New Emerging Neurotropic Virus. Rev Neurol. 2016 Apr 1;62(7):317-28. PubMed PMID: 26988170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus. A1 - Carod-Artal,Francisco J, PY - 2016/3/19/entrez PY - 2016/3/19/pubmed PY - 2017/1/6/medline SP - 317 EP - 28 JF - Revista de neurologia JO - Rev Neurol VL - 62 IS - 7 N2 - INTRODUCTION: The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT: Since 2007, 55 countries in America, Asia, Africa and Oceania have detected local transmission of the virus. This epidemic has affected almost 1.5 million people in Brazil. 80% of the cases are asymptomatic. The symptoms of Zika virus disease include fever, maculopapular rash, arthralgia and non-purulent conjunctivitis. The symptoms are usually self-limiting and last one week. An increase in the incidence of cases of microcephaly, retinal lesions and Guillain-Barre syndrome associated with the Zika virus has been reported. Zika-associated Guillain-Barre syndrome in Polynesia is a pure motor axonal variant. The RNA of the Zika virus has been identified in samples of brain tissue, placenta and amniotic liquid of children with microcephaly and in the still-born infants of women infected by Zika during pregnancy. The reverse transcription polymerase chain reaction test is recommended to detect viral RNA, and serological tests (IgM ELISA and neutralising antibodies) should be conducted to confirm infection by Zika. The differential diagnosis includes infection by the dengue and chikungunya viruses. CONCLUSIONS: Knowledge about the pathogenic mechanisms involved in infection due to Zika virus and its long-term consequences in adults and newborn infants is still limited. SN - 1576-6578 UR - https://www.unboundmedicine.com/medline/citation/26988170/Epidemiology_and_neurological_complications_of_infection_by_the_Zika_virus:_a_new_emerging_neurotropic_virus_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2016152&Revista=RevNeurol DB - PRIME DP - Unbound Medicine ER -