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Animal Models of Vascular Cognitive Impairment and Dementia (VCID).
Cell Mol Neurobiol. 2016 Mar; 36(2):233-9.CM

Abstract

Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer's disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i.e., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). In this review, we will discuss the experimental animal models that have been developed to study these pathologies. We will discuss the limitations and strengths of these models and the important research findings that have advanced the field through the use of the models.

Authors+Show Affiliations

Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, 424 Sanders-Brown Center on Aging, 800 S. Limestone St, Lexington, KY, 40536, USA.Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, 424 Sanders-Brown Center on Aging, 800 S. Limestone St, Lexington, KY, 40536, USA. donna.wilcock@uky.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26988696

Citation

Gooch, Jennifer, and Donna M. Wilcock. "Animal Models of Vascular Cognitive Impairment and Dementia (VCID)." Cellular and Molecular Neurobiology, vol. 36, no. 2, 2016, pp. 233-9.
Gooch J, Wilcock DM. Animal Models of Vascular Cognitive Impairment and Dementia (VCID). Cell Mol Neurobiol. 2016;36(2):233-9.
Gooch, J., & Wilcock, D. M. (2016). Animal Models of Vascular Cognitive Impairment and Dementia (VCID). Cellular and Molecular Neurobiology, 36(2), 233-9. https://doi.org/10.1007/s10571-015-0286-3
Gooch J, Wilcock DM. Animal Models of Vascular Cognitive Impairment and Dementia (VCID). Cell Mol Neurobiol. 2016;36(2):233-9. PubMed PMID: 26988696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Animal Models of Vascular Cognitive Impairment and Dementia (VCID). AU - Gooch,Jennifer, AU - Wilcock,Donna M, Y1 - 2016/03/17/ PY - 2015/08/29/received PY - 2015/10/08/accepted PY - 2016/3/19/entrez PY - 2016/3/19/pubmed PY - 2017/2/7/medline KW - Alzheimer’s disease KW - Animal model KW - Neuropathology KW - Neurovasculature KW - Vascular cognitive impairment and dementia (VCID) SP - 233 EP - 9 JF - Cellular and molecular neurobiology JO - Cell. Mol. Neurobiol. VL - 36 IS - 2 N2 - Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer's disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i.e., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). In this review, we will discuss the experimental animal models that have been developed to study these pathologies. We will discuss the limitations and strengths of these models and the important research findings that have advanced the field through the use of the models. SN - 1573-6830 UR - https://www.unboundmedicine.com/medline/citation/26988696/Animal_Models_of_Vascular_Cognitive_Impairment_and_Dementia__VCID__ L2 - https://doi.org/10.1007/s10571-015-0286-3 DB - PRIME DP - Unbound Medicine ER -