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Overweight, Obesity, and Risk of Age-Related Macular Degeneration.

Abstract

PURPOSE

The aim of this study was to quantify the relationship between categories of body mass index (BMI) and age-related macular degeneration (AMD) risk in different stages.

METHODS

MEDLINE, EMBASE, and ISI Web of Science were searched for all eligible studies on the relationship between BMI and incident early or late AMD. The analyses were based on data extracted from study reports. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of this association, and dose-response relationship was assessed by restricted cubic spline.

RESULTS

Seven prospective cohort studies with 1613 cases identified among 31,151 subjects were included. For overweight, the relationship remained insignificant for its association with both early AMD (RR = 0.92, 95% CI: 0.68-1.15; P = 0.54) and late AMD (RR = 1.09, 95% CI: 0.93-1.25; P = 0.18). A marked 32% increase in the risk of developing late AMD was noted among obese individuals (RR = 1.32, 95% CI: 1.11-1.53, P < 0.01), while obesity showed no significant association with early AMD (RR = 0.91, 95% CI: 0.74-1.08; P = 0.67). Furthermore, elevated BMI showed a linear dose-response relation with AMD risk (Pnonlinearity = 0.17), and the AMD risk increased by 2% (RR = 1.02, 95% CI: 1.01-1.04) for each 1 kg/m2 increase in BMI within the overweight and obese BMI ranges.

CONCLUSIONS

Excess body weight was weakly associated with increase in the risk of AMD in a dose-dependent fashion, especially for its late stage, indicating that keeping normal body weight and avoiding further weight gain may confer potential protection against this disease.

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  • Authors+Show Affiliations

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    The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China 2School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

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    The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.

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    National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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    The School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

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    School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

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    School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

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    Xi'an International University, Xi'an, China.

    School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China 6Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, China.

    Source

    MeSH

    Body Mass Index
    Global Health
    Humans
    Incidence
    Macular Degeneration
    Obesity
    Overweight
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26990164

    Citation

    Zhang, Qian-Yu, et al. "Overweight, Obesity, and Risk of Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science, vol. 57, no. 3, 2016, pp. 1276-83.
    Zhang QY, Tie LJ, Wu SS, et al. Overweight, Obesity, and Risk of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016;57(3):1276-83.
    Zhang, Q. Y., Tie, L. J., Wu, S. S., Lv, P. L., Huang, H. W., Wang, W. Q., ... Ma, L. (2016). Overweight, Obesity, and Risk of Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science, 57(3), pp. 1276-83. doi:10.1167/iovs.15-18637.
    Zhang QY, et al. Overweight, Obesity, and Risk of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016;57(3):1276-83. PubMed PMID: 26990164.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Overweight, Obesity, and Risk of Age-Related Macular Degeneration. AU - Zhang,Qian-Yu, AU - Tie,Li-Jun, AU - Wu,Shan-Shan, AU - Lv,Pei-Lin, AU - Huang,Hong-Wei, AU - Wang,Wei-Qing, AU - Wang,Hui, AU - Ma,Le, PY - 2016/3/19/entrez PY - 2016/3/19/pubmed PY - 2016/7/28/medline SP - 1276 EP - 83 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 57 IS - 3 N2 - PURPOSE: The aim of this study was to quantify the relationship between categories of body mass index (BMI) and age-related macular degeneration (AMD) risk in different stages. METHODS: MEDLINE, EMBASE, and ISI Web of Science were searched for all eligible studies on the relationship between BMI and incident early or late AMD. The analyses were based on data extracted from study reports. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of this association, and dose-response relationship was assessed by restricted cubic spline. RESULTS: Seven prospective cohort studies with 1613 cases identified among 31,151 subjects were included. For overweight, the relationship remained insignificant for its association with both early AMD (RR = 0.92, 95% CI: 0.68-1.15; P = 0.54) and late AMD (RR = 1.09, 95% CI: 0.93-1.25; P = 0.18). A marked 32% increase in the risk of developing late AMD was noted among obese individuals (RR = 1.32, 95% CI: 1.11-1.53, P < 0.01), while obesity showed no significant association with early AMD (RR = 0.91, 95% CI: 0.74-1.08; P = 0.67). Furthermore, elevated BMI showed a linear dose-response relation with AMD risk (Pnonlinearity = 0.17), and the AMD risk increased by 2% (RR = 1.02, 95% CI: 1.01-1.04) for each 1 kg/m2 increase in BMI within the overweight and obese BMI ranges. CONCLUSIONS: Excess body weight was weakly associated with increase in the risk of AMD in a dose-dependent fashion, especially for its late stage, indicating that keeping normal body weight and avoiding further weight gain may confer potential protection against this disease. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/26990164/full_citation L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.15-18637 DB - PRIME DP - Unbound Medicine ER -