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DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population.
Braz J Microbiol 2016 Apr-Jun; 47(2):389-93BJ

Abstract

β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).

Authors+Show Affiliations

Department of Genetics, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil. Electronic address: ronaldocelerino@yahoo.com.br.Department of Genetics, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Department of Pathology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.Department of Genetics, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.Department of Immunology, Aggeu Magalhães Research Center (CPqAM - FIOCRUZ - Pernambuco), Recife, Pernambuco, Brazil.Department of Immunology, Aggeu Magalhães Research Center (CPqAM - FIOCRUZ - Pernambuco), Recife, Pernambuco, Brazil.Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.Department of Genetics, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26991287

Citation

Celerino da Silva, Ronaldo, et al. "DEFB1 Gene Polymorphisms and Tuberculosis in a Northeastern Brazilian Population." Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology], vol. 47, no. 2, 2016, pp. 389-93.
Celerino da Silva R, da Cruz HL, Brandão LA, et al. DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. Braz J Microbiol. 2016;47(2):389-93.
Celerino da Silva, R., da Cruz, H. L., Brandão, L. A., Guimarães, R. L., Montenegro, L. M., Schindler, H. C., ... Crovella, S. (2016). DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology], 47(2), pp. 389-93. doi:10.1016/j.bjm.2015.09.001.
Celerino da Silva R, et al. DEFB1 Gene Polymorphisms and Tuberculosis in a Northeastern Brazilian Population. Braz J Microbiol. 2016;47(2):389-93. PubMed PMID: 26991287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. AU - Celerino da Silva,Ronaldo, AU - da Cruz,Heidi Lacerda Alves, AU - Brandão,Lucas André Cavalcanti, AU - Guimarães,Rafael Lima, AU - Montenegro,Lilian Maria Lapa, AU - Schindler,Haiana Charifker, AU - Segat,Ludovica, AU - Crovella,Sergio, Y1 - 2016/03/02/ PY - 2014/09/17/received PY - 2015/09/05/accepted PY - 2016/3/19/entrez PY - 2016/3/19/pubmed PY - 2016/12/15/medline KW - DEFB1 KW - Genotyping KW - Innate immunity KW - Polymorphism KW - Tuberculosis SP - 389 EP - 93 JF - Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] JO - Braz. J. Microbiol. VL - 47 IS - 2 N2 - β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50). SN - 1678-4405 UR - https://www.unboundmedicine.com/medline/citation/26991287/DEFB1_gene_polymorphisms_and_tuberculosis_in_a_Northeastern_Brazilian_population_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26991287/ DB - PRIME DP - Unbound Medicine ER -